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STRUCTURAL STUDIES OF MUTANTS OF T4 LYSOZYME THAT ALTER HYDROPHOBIC STABILIZATION
Descriptor:	T4 LYSOZYME
Authors:	Wilson, K, Faber, R, Dao-Pin, S, Matthews, B.W.
Deposit date:	1989-05-01
Release date:	1990-01-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural studies of mutants of T4 lysozyme that alter hydrophobic stabilization. J.Biol.Chem., 264, 1989

7USF

Mouse mammary tumor virus strand transfer complex intasome
Descriptor:	CALCIUM ION, Integrase, ZINC ION, ...
Authors:	Jozwik, I, Lyumkis, D.
Deposit date:	2022-04-25
Release date:	2022-08-24
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	B-to-A transition in target DNA during retroviral integration. Nucleic Acids Res., 50, 2022

7UT1

Higher-order assembly of multiple MMTV strand transfer complex intasomes
Descriptor:	Integrase, ZINC ION, tDNA strand, ...
Authors:	Jozwik, I, Lyumkis, D.
Deposit date:	2022-04-26
Release date:	2022-08-24
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	B-to-A transition in target DNA during retroviral integration. Nucleic Acids Res., 50, 2022

5F3H

Structure of myostatin in complex with humanized RK35 antibody
Descriptor:	Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain
Authors:	Parris, K.D, Mosyak, L.
Deposit date:	2015-12-02
Release date:	2016-09-28
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016

5F3B

Structure of myostatin in complex with chimeric RK35 antibody
Descriptor:	GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
Authors:	Parris, K.D, Mosyak, L.
Deposit date:	2015-12-02
Release date:	2016-09-28
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016

6SZM

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009
Descriptor:	1,2-ETHANEDIOL, 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine, AMMONIUM ION, ...
Authors:	Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
Deposit date:	2019-10-02
Release date:	2019-10-16
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.42 Å)
Cite:	Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J.Med.Chem., 63, 2020

7K45

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), ...
Authors:	Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-14
Release date:	2020-10-07
Last modified:	2024-08-07
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K43

SARS-CoV-2 spike in complex with the S2M11 neutralizing antibody Fab fragment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2M11 Fab fragment (heavy chain), ...
Authors:	Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-14
Release date:	2020-10-07
Last modified:	2021-01-27
Method:	ELECTRON MICROSCOPY (2.6 Å)
Cite:	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K3Q

An ultra-potent human neutralizing antibody locks the SARS-CoV-2 spike in the closed conformation
Descriptor:	1,2-ETHANEDIOL, Fab fragment of S2E12 monoclonal antibody, heavy chain, ...
Authors:	Snell, G, Czudnochowski, N, Ng, C.
Deposit date:	2020-09-12
Release date:	2020-10-07
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.38 Å)
Cite:	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K4N

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2E12 neutralizing antibody Fab fragment (heavy chain), ...
Authors:	Tortorici, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-15
Release date:	2020-10-07
Last modified:	2020-12-02
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

192L

A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
Descriptor:	2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X.-J, Matthews, B.W.
Deposit date:	1995-06-13
Release date:	1995-09-15
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis. Biophys.Chem., 101-102, 2002

190L

A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X.-J, Matthews, B.W.
Deposit date:	1995-06-13
Release date:	1995-09-15
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis. Biophys.Chem., 101-102, 2002

191L

A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
Descriptor:	2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X.-J, Matthews, B.W.
Deposit date:	1995-06-13
Release date:	1995-09-15
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis. Biophys.Chem., 101-102, 2002

1L09

CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
Descriptor:	T4 LYSOZYME
Authors:	Dao-Pin, S, Bell, J, Alber, T, Matthews, B.W.
Deposit date:	1988-02-05
Release date:	1988-04-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987

5LZM

COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Bell, J.A, Wilson, K, Zhang, X.-J, Faber, H.R, Nicholson, H, Matthews, B.W.
Deposit date:	1991-01-25
Release date:	1992-07-15
Last modified:	2021-06-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths. Proteins, 10, 1991

1L39

CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry, 30, 1991

1L62

ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Nicholson, H, Matthews, B.W.
Deposit date:	1991-05-06
Release date:	1991-10-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991

1L57

ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Nicholson, H, Matthews, B.W.
Deposit date:	1991-05-06
Release date:	1991-10-15
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991

1L46

CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991

1L42

CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991

1L59

ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Nicholson, H, Matthews, B.W.
Deposit date:	1991-05-06
Release date:	1991-10-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991

1L41

CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry, 30, 1991

1L48

STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2022-11-23
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J.Mol.Biol., 221, 1991

1L51

STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J.Mol.Biol., 221, 1991

1L37

CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor:	T4 LYSOZYME
Authors:	Daopin, S, Matthews, B.W.
Deposit date:	1991-01-28
Release date:	1991-10-15
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry, 30, 1991

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