7K4N

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment

Summary for 7K4N

EMDB information22668
DescriptorSpike glycoprotein, S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), ... (5 entities in total)
Functional Keywordssars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
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Total number of polymer chains9
Total molecular weight516569.34
Authors
Primary citation
Tortorici, M.A.,Beltramello, M.,Lempp, F.A.,Pinto, D.,Dang, H.V.,Rosen, L.E.,McCallum, M.,Bowen, J.,Minola, A.,Jaconi, S.,Zatta, F.,De Marco, A.,Guarino, B.,Bianchi, S.,Lauron, E.J.,Tucker, H.,Zhou, J.,Peter, A.,Havenar-Daughton, C.,Wojcechowskyj, J.A.,Case, J.B.,Chen, R.E.,Kaiser, H.,Montiel-Ruiz, M.,Meury, M.,Czudnochowski, N.,Spreafico, R.,Dillen, J.,Ng, C.,Sprugasci, N.,Culap, K.,Benigni, F.,Abdelnabi, R.,Foo, S.C.,Schmid, M.A.,Cameroni, E.,Riva, A.,Gabrieli, A.,Galli, M.,Pizzuto, M.S.,Neyts, J.,Diamond, M.S.,Virgin, H.W.,Snell, G.,Corti, D.,Fink, K.,Veesler, D.
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
PubMed: 32972994 (PDB entries with the same primary citation)
DOI: 10.1126/science.abe3354
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers00 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-10-14