SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)

Summary for 7K45

EMDB information22660
DescriptorS2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), Spike glycoprotein, ... (4 entities in total)
Functional Keywordssars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight168058.89
Tortorici, M.A.,Veesler, D. (deposition date: 2020-09-14, release date: 2020-10-07)
Primary citation
Tortorici, M.A.,Beltramello, M.,Lempp, F.A.,Pinto, D.,Dang, H.V.,Rosen, L.E.,McCallum, M.,Bowen, J.,Minola, A.,Jaconi, S.,Zatta, F.,De Marco, A.,Guarino, B.,Bianchi, S.,Lauron, E.J.,Tucker, H.,Zhou, J.,Peter, A.,Havenar-Daughton, C.,Wojcechowskyj, J.A.,Case, J.B.,Chen, R.E.,Kaiser, H.,Montiel-Ruiz, M.,Meury, M.,Czudnochowski, N.,Spreafico, R.,Dillen, J.,Ng, C.,Sprugasci, N.,Culap, K.,Benigni, F.,Abdelnabi, R.,Foo, S.C.,Schmid, M.A.,Cameroni, E.,Riva, A.,Gabrieli, A.,Galli, M.,Pizzuto, M.S.,Neyts, J.,Diamond, M.S.,Virgin, H.W.,Snell, G.,Corti, D.,Fink, K.,Veesler, D.
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
PubMed: 32972994 (PDB entries with the same primary citation)
DOI: 10.1126/science.abe3354
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers00 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-10-14