2V9S
 
 | | Second LRR domain of human Slit2 | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SLIT HOMOLOG 2 PROTEIN N-PRODUCT | | Authors: | Morlot, C, Cusack, S, McCarthy, A.A. | | Deposit date: | 2007-08-25 | | Release date: | 2007-09-25 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Insights Into the Slit-Robo Complex.
Proc.Natl.Acad.Sci.USA, 104, 2007
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2V9R
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4WRT
 | | Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | | Descriptor: | Influenza virus polymerase vRNA promoter 3' end, Influenza virus polymerase vRNA promoter 5' end, PA, ... | | Authors: | Reich, S, Guilligay, D, Pflug, A, Cusack, S. | | Deposit date: | 2014-10-25 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
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2I4O
 | | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Proline-tRNA ligase | | Authors: | Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S. | | Deposit date: | 2006-08-22 | | Release date: | 2006-10-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
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6LPF
 | | The crystal structure of human cytoplasmic LRS | | Descriptor: | 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, ... | | Authors: | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | | Deposit date: | 2020-01-10 | | Release date: | 2020-03-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.
Nucleic Acids Res., 48, 2020
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6EVJ
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6EVK
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1NSC
 | | INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, N-acetyl-alpha-neuraminic acid, ... | | Authors: | Burmeister, W.P, Ruigrok, R.W.H, Cusack, S. | | Deposit date: | 1993-05-24 | | Release date: | 1993-10-31 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Influenza B virus neuraminidase can synthesize its own inhibitor.
Structure, 1, 1993
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1NSD
 | | INFLUENZA B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Burmeister, W.P, Ruigrok, R.W.H, Cusack, S. | | Deposit date: | 1993-05-24 | | Release date: | 1993-10-31 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Influenza B virus neuraminidase can synthesize its own inhibitor.
Structure, 1, 1993
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5D98
 | | Influenza C Virus RNA-dependent RNA Polymerase - Space group P43212 | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E. | | Deposit date: | 2015-08-18 | | Release date: | 2015-10-21 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Nature, 527, 2015
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2V0G
 | | LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site. | | Descriptor: | AMINOACYL-TRNA SYNTHETASE, LEUCINE, MERCURY (II) ION, ... | | Authors: | Rock, F, Mao, W, Yaremchuk, A, Tukalo, M, Crepin, T, Zhou, H, Zhang, Y, Hernandez, V, Akama, T, Baker, S, Plattner, J, Shapiro, L, Martinis, S.A, Benkovic, S.J, Cusack, S, Alley, M.R.K. | | Deposit date: | 2007-05-14 | | Release date: | 2007-07-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
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5D9A
 | | Influenza C Virus RNA-dependent RNA Polymerase - Space group P212121 | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | | Authors: | Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E. | | Deposit date: | 2015-08-18 | | Release date: | 2015-10-21 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Nature, 527, 2015
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2V0C
 | | LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site | | Descriptor: | AMINOACYL-TRNA SYNTHETASE, LEUCINE, SULFATE ION, ... | | Authors: | Rock, F, Mao, W, Yaremchuk, A, Tukalo, M, Crepin, T, Zhou, H, Zhang, Y, Hernandez, V, Akama, T, Baker, S, Plattner, J, Shapiro, L, Martinis, S.A, Benkovic, S.J, Cusack, S, Alley, M.R.K. | | Deposit date: | 2007-05-14 | | Release date: | 2007-07-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
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6T2C
 | | Bat Influenza A polymerase recycling complex | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | | Deposit date: | 2019-10-08 | | Release date: | 2020-04-15 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
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4UYK
 | | Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation | | Descriptor: | SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA | | Authors: | Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. | | Deposit date: | 2014-09-01 | | Release date: | 2014-11-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation.
RNA, 20, 2014
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4V4U
 | | The quasi-atomic model of Human Adenovirus type 5 capsid | | Descriptor: | HEXON PROTEIN, N-TERMINAL PEPTIDE OF FIBER PROTEIN, PENTON PROTEIN | | Authors: | Fabry, C.M.S, Rosa-Calatrava, M, Conway, J.F, Zubieta, C, Cusack, S, Ruigrok, R.W.H, Schoehn, G. | | Deposit date: | 2005-03-03 | | Release date: | 2014-07-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | A Quasi-Atomic Model of Human Adenovirus Type 5 Capsid.
Embo J., 24, 2005
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4CKB
 | | Vaccinia virus capping enzyme complexed with GTP and SAH | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MRNA-CAPPING ENZYME CATALYTIC SUBUNIT, MRNA-CAPPING ENZYME REGULATORY SUBUNIT, ... | | Authors: | Kyrieleis, O.J.P, Chang, J, de la Pena, M, Shuman, S, Cusack, S. | | Deposit date: | 2014-01-02 | | Release date: | 2014-03-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure, 22, 2014
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4CKC
 | | Vaccinia virus capping enzyme complexed with SAH (monoclinic form) | | Descriptor: | MRNA-CAPPING ENZYME CATALYTIC SUBUNIT, MRNA-CAPPING ENZYME REGULATORY SUBUNIT, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Kyrieleis, O.J.P, Chang, J, de la Pena, M, Shuman, S, Cusack, S. | | Deposit date: | 2014-01-02 | | Release date: | 2014-03-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure, 22, 2014
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4CKE
 | | Vaccinia virus capping enzyme complexed with SAH in P1 form | | Descriptor: | MRNA-CAPPING ENZYME CATALYTIC SUBUNIT, MRNA-CAPPING ENZYME REGULATORY SUBUNIT, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Kyrieleis, O.J.P, Chang, J, de la Pena, M, Shuman, S, Cusack, S. | | Deposit date: | 2014-01-03 | | Release date: | 2014-03-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure, 22, 2014
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6Z8K
 | | La Crosse virus polymerase at elongation mimicking stage | | Descriptor: | La Crosse virus 3' vRNA (1-16), La Crosse virus 5' vRNA (9-16), La Crosse virus 5' vRNA 1-10, ... | | Authors: | Arragain, B, Effantin, G, Schoehn, G, Cusack, S, Malet, H. | | Deposit date: | 2020-06-02 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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1H4S
 | | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG) and a prolyl-adenylate analogue | | Descriptor: | '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, PROLYL-TRNA SYNTHETASE, SULFATE ION, ... | | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | | Deposit date: | 2001-05-14 | | Release date: | 2001-06-18 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
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1H4T
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1HC7
 | | Prolyl-tRNA synthetase from Thermus thermophilus | | Descriptor: | PROLYL-TRNA SYNTHETASE, ZINC ION | | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | | Deposit date: | 2001-04-26 | | Release date: | 2001-06-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
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1H4Q
 | | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG), ATP and prolinol | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PROLYL-TRNA SYNTHETASE, PYRROLIDINE-2-CARBALDEHYDE, ... | | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | | Deposit date: | 2001-05-13 | | Release date: | 2001-06-18 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
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4D25
 | | Crystal structure of the Bombyx mori Vasa helicase (E339Q) in complex with RNA and AMPPNP | | Descriptor: | 5'-R(*UP*GP*AP*CP*AP*UP)-3', BMVLG PROTEIN, GLYCEROL, ... | | Authors: | Spinelli, P, Pillai, R.S, Kadlec, J, Cusack, S. | | Deposit date: | 2014-05-07 | | Release date: | 2014-06-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | RNA Clamping by Vasa Assembles a Pirna Amplifier Complex on Transposon Transcripts.
Cell(Cambridge,Mass.), 157, 2014
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