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1HAY
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BU of 1hay by Molmil
Snapshots of serine protease catalysis: (B) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 jumped to pH 10 for 10 seconds
Descriptor: CALCIUM ION, ELASTASE 1, SULFATE ION
Authors:Wilmouth, R.C, Edman, K, Neutze, R, Wright, P.A, Clifton, I.J, Schneider, T.R, Schofield, C.J, Hajdu, J.
Deposit date:2001-04-10
Release date:2001-08-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-Ray Snapshots of Serine Protease Catalysis Reveal a Tetrahedral Intermediate
Nat.Struct.Biol., 8, 2001
1LVY
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BU of 1lvy by Molmil
PORCINE ELASTASE
Descriptor: CALCIUM ION, ELASTASE, SULFATE ION
Authors:Schiltz, M, Prange, T.
Deposit date:1996-07-20
Release date:1997-01-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:High-pressure krypton gas and statistical heavy-atom refinement: a successful combination of tools for macromolecular structure determination.
Acta Crystallogr.,Sect.D, 53, 1997
8S9H
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BU of 8s9h by Molmil
Crystal structure of monkey TLR7 ectodomain with compound 14
Descriptor: (3S)-3-{[5-amino-1-({3-methoxy-5-[1-(oxan-4-yl)piperidin-4-yl]pyridin-2-yl}methyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl]amino}hexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Critton, D.A.
Deposit date:2023-03-28
Release date:2024-02-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.437 Å)
Cite:Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
Acs Med.Chem.Lett., 15, 2024
1BTU
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BU of 1btu by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4R)-1-TOLUENESULPHONYL-3-ETHYL-AZETIDIN-2-ONE-4-CARBOXYLIC ACID
Descriptor: (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid, CALCIUM ION, ELASTASE, ...
Authors:Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:1998-09-01
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
Biochemistry, 37, 1998
8TTY
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BU of 8tty by Molmil
Crystal structure of monkey TLR7 ectodomain with compound 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N~7~-butyl-2-({4-[(cyclobutylamino)methyl]-2-methoxyphenyl}methyl)-2H-pyrazolo[4,3-d]pyrimidine-5,7-diamine, ...
Authors:Critton, D.A.
Deposit date:2023-08-15
Release date:2024-02-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
Acs Med.Chem.Lett., 15, 2024
8TTZ
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BU of 8ttz by Molmil
Crystal structure of monkey TLR7 ectodomain with compound 20
Descriptor: (3S)-3-({5-amino-1-[(2-methoxy-4-{[(oxan-4-yl)amino]methyl}phenyl)methyl]-1H-pyrazolo[4,3-d]pyrimidin-7-yl}amino)hexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Critton, D.A.
Deposit date:2023-08-15
Release date:2024-02-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
Acs Med.Chem.Lett., 15, 2024
2MOA
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BU of 2moa by Molmil
Solution NMR structure of peptide ImI1 (peak 2)
Descriptor: Alpha-conotoxin ImI
Authors:Heinis, C, Chen, S.
Deposit date:2014-04-24
Release date:2014-09-24
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
1YNQ
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BU of 1ynq by Molmil
aldo-keto reductase AKR11C1 from Bacillus halodurans (holo form)
Descriptor: GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ...
Authors:Marquardt, T, Kostrewa, D, Winkler, F.K, Li, X.D.
Deposit date:2005-01-25
Release date:2005-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution Crystal Structure of AKR11C1 from Bacillus halodurans: An NADPH-dependent 4-Hydroxy-2,3-trans-nonenal Reductase
J.Mol.Biol., 354, 2005
3LMG
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BU of 3lmg by Molmil
Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3
Authors:Shi, F, Lemmon, M.A.
Deposit date:2010-01-30
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.
Proc.Natl.Acad.Sci.USA, 107, 2010
1QGF
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BU of 1qgf by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3R, 4S)N-PARA-TOLUENESULPHONYL-3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wilmouth, R.C, Kassamally, S, Westwood, N.J, Sheppard, R.J, Claridge, T.D.W, Wright, P.A, Pritchard, G.J, Schofield, C.J.
Deposit date:1999-04-27
Release date:1999-12-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
Biochemistry, 38, 1999
1QNJ
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BU of 1qnj by Molmil
THE STRUCTURE OF NATIVE PORCINE PANCREATIC ELASTASE AT ATOMIC RESOLUTION (1.1 A)
Descriptor: ELASTASE, SODIUM ION, SULFATE ION
Authors:Wurtele, M, Hahn, M, Hilpert, K, Hohne, W.
Deposit date:1999-10-15
Release date:2000-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic Resolution Structure of Native Porcine Pancreatic Elastase at 1.1 A
Acta Crystallogr.,Sect.D, 56, 2000
1YNP
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BU of 1ynp by Molmil
aldo-keto reductase AKR11C1 from Bacillus halodurans (apo form)
Descriptor: GLYCEROL, SODIUM ION, SULFATE ION, ...
Authors:Marquardt, T, Kostrewa, D, Winkler, F.K, Li, X.D.
Deposit date:2005-01-25
Release date:2005-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High-resolution Crystal Structure of AKR11C1 from Bacillus halodurans: An NADPH-dependent 4-Hydroxy-2,3-trans-nonenal Reductase
J.Mol.Biol., 354, 2005
1QIX
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BU of 1qix by Molmil
Porcine pancreatic elastase complexed with human beta-casomorphin-7
Descriptor: BETA-CASOMORPHIN-7, CALCIUM ION, ELASTASE, ...
Authors:Wilmouth, R.C, Clifton, I.J, Hajdu, J, Schofield, C.J.
Deposit date:1999-06-18
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Specific Acyl-Enzyme Complex Formed between Beta-Casomorphin-7 and Porcine Pancreatic Elastase
Nat.Struct.Biol., 4, 1997
1E37
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BU of 1e37 by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR 1 MINUTE
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:2000-06-06
Release date:2000-10-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:'Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes
Biochem.J., 351, 2000
1E38
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BU of 1e38 by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR 2 MINUTES
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:2000-06-06
Release date:2000-10-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:'Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes
Biochem.J., 351, 2000
1E36
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BU of 1e36 by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:2000-06-06
Release date:2000-10-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:'Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes
Biochem.J., 351, 2000
1E35
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BU of 1e35 by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-TOLUENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR TWO MINUTES
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:2000-06-06
Release date:2000-10-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:'Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes
Biochem.J., 351, 2000
1E34
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BU of 1e34 by Molmil
PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA- TOLUENESULPHONYL-3-ETHYL-4-(CARBOXYLIC ACID) PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR ONE MINUTE
Descriptor: (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:2000-06-06
Release date:2000-10-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:`Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes
Biochem.J., 351, 2000
1ELF
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BU of 1elf by Molmil
NATURE OF THE INACTIVATION OF ELASTASE BY N-PEPTIDYL-O-AROYL HYDROXYLAMINE AS A FUNCTION OF PH
Descriptor: (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE, CALCIUM ION, PORCINE PANCREATIC ELASTASE, ...
Authors:Ding, X, Rasmussen, B, Demuth, H.-U, Ringe, D, Steinmetz, A.C.U.
Deposit date:1995-03-13
Release date:1995-07-10
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH.
Biochemistry, 34, 1995
1ELG
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BU of 1elg by Molmil
NATURE OF THE INACTIVATION OF ELASTASE BY N-PEPTIDYL-O-AROYL HYDROXYLAMINE AS A FUNCTION OF PH
Descriptor: (TERT-BUTYLOXYCARBONYL)-ALANYL-ALANYL-AMINE, CALCIUM ION, PORCINE PANCREATIC ELASTASE
Authors:Ding, X, Rasmussen, B, Demuth, H.-U, Ringe, D, Steinmetz, A.C.U.
Deposit date:1995-03-13
Release date:1995-07-10
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH.
Biochemistry, 34, 1995
1EAI
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BU of 1eai by Molmil
COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE
Descriptor: PROTEIN (CHYMOTRYPSIN/ELASTASE ISOINHIBITOR 1), PROTEIN (ELASTASE)
Authors:Huang, K, Strynadka, N.C.J, Bernard, V.D, Peanasky, R.J, James, M.N.G.
Deposit date:1999-03-25
Release date:1999-04-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Structure, 2, 1994
1ELT
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BU of 1elt by Molmil
STRUCTURE OF NATIVE PANCREATIC ELASTASE FROM NORTH ATLANTIC SALMON AT 1.61 ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, ELASTASE
Authors:Berglund, G.I, Smalaas, A.O.
Deposit date:1995-01-02
Release date:1996-01-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution.
Acta Crystallogr.,Sect.D, 51, 1995
1ESA
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BU of 1esa by Molmil
DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE
Descriptor: CALCIUM ION, PORCINE PANCREATIC ELASTASE, SULFATE ION
Authors:Ding, X, Rasmussen, B, Petsko, G.A, Ringe, D.
Deposit date:1994-02-04
Release date:1994-04-30
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase.
Biochemistry, 33, 1994
1IND
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BU of 1ind by Molmil
HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE
Descriptor: IGG1-LAMBDA CHA255 FAB (HEAVY CHAIN), IGG1-LAMBDA CHA255 FAB (LIGHT CHAIN), INDIUM (III) ION, ...
Authors:Love, R.A, Butler, W.F.
Deposit date:1993-06-14
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate.
Biochemistry, 32, 1993
1INE
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BU of 1ine by Molmil
HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE
Descriptor: FE (III) ION, IGG1-LAMBDA CHA255 FAB (HEAVY CHAIN), IGG1-LAMBDA CHA255 FAB (LIGHT CHAIN), ...
Authors:Love, R.A, Butler, W.F.
Deposit date:1993-06-14
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate.
Biochemistry, 32, 1993

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数据于2024-06-26公开中

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