4OS1
Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK601 (bicyclic 1)
Summary for 4OS1
| Entry DOI | 10.2210/pdb4os1/pdb |
| Related | 4GLY 4OS2 4OS4 4OS5 4OS6 4OS7 |
| Related PRD ID | PRD_001222 |
| Descriptor | Urokinase-type plasminogen activator, bicyclic peptide UK601 (bicyclic 1), SULFATE ION, ... (5 entities in total) |
| Functional Keywords | bicyclic peptide, inhibitor, protease, disulfide bridges, cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P00749 |
| Total number of polymer chains | 2 |
| Total formula weight | 29387.46 |
| Authors | Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2014-02-12, release date: 2014-09-24, Last modification date: 2021-06-02) |
| Primary citation | Chen, S.,Gopalakrishnan, R.,Schaer, T.,Marger, F.,Hovius, R.,Bertrand, D.,Pojer, F.,Heinis, C. Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nat Chem, 6:1009-1016, 2014 Cited by PubMed: 25343607DOI: 10.1038/nchem.2043 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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