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4OS1

Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK601 (bicyclic 1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
ALYS61
AHIS100
ATHR177
ALYS179
AMET180
AHOH417

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 302
ChainResidue
ALYS187
AARG35
AHIS37
AARG37

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 303
ChainResidue
ALYS110
ALYS223
AHOH490

site_idAC4
Number of Residues29
DetailsBINDING SITE FOR CHAIN B OF BICYCLIC PEPTIDE UK601 (BICYCLIC 1)
ChainResidue
AGLU20
APHE21
ATHR23
AARG35
AHIS57
ACYS58
AASP60
ATYR60
ATYR64
AHIS99
ASER174
AASP189
ASER190
ACYS191
AGLN192
AGLY193
ASER195
ASER214
ATRP215
AGLY218
AGLY226
AHOH444
AHOH469
AHOH471
BHOH101
BHOH102
BHOH103
BHOH104
BHOH105

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
AILE53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
ASER146

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AGLN145

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PDB entries from 2024-05-01

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