4HJO

Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib

Summary for 4HJO

Entry DOI	10.2210/pdb4hjo/pdb
Descriptor	Epidermal growth factor receptor, [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE (3 entities in total)
Functional Keywords	inactive tyrosine kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38950.01
Authors	Park, J.H.,Lemmon, M.A. (deposition date: 2012-10-13, release date: 2012-11-14, Last modification date: 2023-09-20)
Primary citation	Park, J.H.,Liu, Y.,Lemmon, M.A.,Radhakrishnan, R. Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain. Biochem.J., 448:417-423, 2012 Cited by PubMed: 23101586 DOI: 10.1042/BJ20121513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation