4HJO
Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 337 | 38556.6 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE | non-polymer | 393.4 | 1 | Chemie (AQ4) | |||
| 3 | C (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 662 | - | expression tag |
| Lys 663 | - | expression tag |
| Lys 664 | - | expression tag |
| Gly 665 | - | expression tag |
| His 666 | - | expression tag |
| His 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
| His 670 | - | expression tag |
| Gly 671 | - | expression tag |
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38556.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 393.4 | |
| All* | Total formula weight | 38950.0 |
