4HJO

Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epidermal growth factor receptor	polymer	337	38556.6	1	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2	A	[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE	non-polymer		393.4	1	Chemie (AQ4)
3		water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 672 - 998 (UniProt: P00533)

PDB	External Database	Details
Met 662	-	expression tag
Lys 663	-	expression tag
Lys 664	-	expression tag
Gly 665	-	expression tag
His 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
Gly 671	-	expression tag
Arg 924	Val 948	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38556.6
Non-Polymers*	Number of molecules	1
	Total formula weight	393.4
All*	Total formula weight	38950.0

*Water molecules are not included.