6MZ1
 
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7V35
 | | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex | | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-08-10 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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7VAB
 | | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex | | Descriptor: | CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-08-28 | | Release date: | 2022-03-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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7VBI
 | | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | Deposit date: | 2021-08-31 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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8KGN
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA (38-MER), DNA topoisomerase 2 | | Authors: | Cong, J, Xin, Y, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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8KGT
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2 | | Authors: | Cong, J, Xin, Y, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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8KGS
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA topoisomerase 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Cong, J, Xin, Y, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.603 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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8KGL
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8KGR
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA (32-MER), DNA (33-MER), DNA topoisomerase 2, ... | | Authors: | Cong, J, Xin, U, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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8KGM
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA (38-MER), DNA topoisomerase 2 | | Authors: | Cong, J, Xin, Y, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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8KGP
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8KGQ
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA (38-MER), DNA topoisomerase 2 | | Authors: | Cong, J, Xin, Y, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Structural insights into the DNA topoisomerase II of the African swine fever virus.
Nat Commun, 15, 2024
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5H5U
 | | Mechanistic insights into the alternative translation termination by ArfA and RF2 | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Ma, C, Kurita, D, Li, N, Chen, Y, Himeno, H, Gao, N. | | Deposit date: | 2016-11-09 | | Release date: | 2017-01-25 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Mechanistic insights into the alternative translation termination by ArfA and RF2
Nature, 541, 2017
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6O3R
 | | Crystal Structure of NDM-1 D199N with Compound 7 | | Descriptor: | Carbapenem Hydrolyzing Class B Metallo beta lactamase NDM-1, ZINC ION, [(5-methoxy-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid | | Authors: | Akhtar, A, Chen, Y. | | Deposit date: | 2019-02-27 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
J.Med.Chem., 62, 2019
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6NY7
 | | Crystal Structure of NDM-1 D199N with Compound 16 | | Descriptor: | Carbapenem Hydrolyzing Class B Metallo beta lactamase NDM-1, ZINC ION, [(5,7-dibromo-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid | | Authors: | Akhtar, A, Chen, Y. | | Deposit date: | 2019-02-11 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
J.Med.Chem., 62, 2019
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6OOH
 | | CTX-M-27 Beta Lactamase with Compound 14 | | Descriptor: | 3-(1H-pyrazol-1-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide, Beta-lactamase | | Authors: | Kemp, M, Chen, Y. | | Deposit date: | 2019-04-23 | | Release date: | 2020-07-01 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.499 Å) | | Cite: | An Empirical Study of Amide-Heteroarene pi-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase.
Org Chem Front, 6, 2019
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6LRS
 | | Cryo-EM structure of RbcL8-RbcS4 from Anabaena sp. PCC 7120 | | Descriptor: | Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain | | Authors: | Xia, L.Y, Jiang, Y.L, Kong, W.W, Sun, H, Li, W.F, Chen, Y, Zhou, C.Z. | | Deposit date: | 2020-01-16 | | Release date: | 2020-07-15 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1.
Nat.Plants, 6, 2020
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3QRF
 | | Structure of a domain-swapped FOXP3 dimer | | Descriptor: | Forkhead box protein P3, MAGNESIUM ION, Nuclear factor of activated T-cells, ... | | Authors: | Bandukwala, H.S, Wu, Y, Feurer, M, Chen, Y, Barbosa, B, Ghosh, S, Stroud, J.C, Benoist, C, Mathis, D, Rao, A, Chen, L. | | Deposit date: | 2011-02-17 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
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8J0H
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7YBF
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7YIB
 | | Crystal structure of wild-type Cap4 SAVED domain-containing receptor from Enterobacter cloacae | | Descriptor: | CD-NTase-associated protein 4, CHLORIDE ION | | Authors: | Ko, T.-P, Yang, C.-S, Hou, M.-H, Wang, Y.-C, Chen, Y. | | Deposit date: | 2022-07-15 | | Release date: | 2023-05-31 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Specific recognition of cyclic oligonucleotides by Cap4 for phage infection.
Int.J.Biol.Macromol., 237, 2023
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7YIA
 | | Crystal structure of K74A mutant of Cap4 SAVED domain-containing receptor from Enterobacter cloacae | | Descriptor: | CD-NTase-associated protein 4, MAGNESIUM ION | | Authors: | Ko, T.-P, Yang, C.-S, Hou, M.-H, Wang, Y.-C, Chen, Y. | | Deposit date: | 2022-07-15 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.428 Å) | | Cite: | Specific recognition of cyclic oligonucleotides by Cap4 for phage infection.
Int.J.Biol.Macromol., 237, 2023
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6BD4
 | | Crystal structure of human apo-Frizzled4 receptor | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ... | | Authors: | Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F. | | Deposit date: | 2017-10-21 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
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5YBX
 | | Crystal structure of the N-terminal domain of Bqt4 in S.pombe | | Descriptor: | Bouquet formation protein 4 | | Authors: | Hu, C, Chen, Y. | | Deposit date: | 2017-09-05 | | Release date: | 2018-09-19 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.
Structure, 27, 2019
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8IJR
 | | The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine | | Descriptor: | (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1 | | Authors: | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | | Deposit date: | 2023-02-28 | | Release date: | 2024-02-28 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 31, 2024
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