6O3R

Crystal Structure of NDM-1 D199N with Compound 7

Summary for 6O3R

Entry DOI	10.2210/pdb6o3r/pdb
Descriptor	Carbapenem Hydrolyzing Class B Metallo beta lactamase NDM-1, ZINC ION, [(5-methoxy-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (4 entities in total)
Functional Keywords	carbapenemase, phosphonate, inhibitor, complex, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	25016.71
Authors	Akhtar, A.,Chen, Y. (deposition date: 2019-02-27, release date: 2019-09-25, Last modification date: 2023-10-11)
Primary citation	Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651 DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation