6O3R
Crystal Structure of NDM-1 D199N with Compound 7
Summary for 6O3R
Entry DOI | 10.2210/pdb6o3r/pdb |
Descriptor | Carbapenem Hydrolyzing Class B Metallo beta lactamase NDM-1, ZINC ION, [(5-methoxy-7-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (4 entities in total) |
Functional Keywords | carbapenemase, phosphonate, inhibitor, complex, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 25016.71 |
Authors | Akhtar, A.,Chen, Y. (deposition date: 2019-02-27, release date: 2019-09-25, Last modification date: 2023-10-11) |
Primary citation | Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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