6O3R

Crystal Structure of NDM-1 D199N with Compound 7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS120
A	HIS122
A	HIS189
A	HOH421
A	HOH441

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP124
A	CYS208
A	HIS250
A	XJE303

---

site_id	AC3
Number of Residues	16
Details	binding site for residue XJE A 303

Chain	Residue
A	MET67
A	PHE70
A	VAL73
A	TRP93
A	ASP124
A	HIS189
A	CYS208
A	HIS250
A	ZN302
A	HOH421
A	HOH422
A	HOH435
A	HOH441
A	HOH450
A	HOH464
A	HOH511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530

Chain	Residue	Details
A	HIS120
A	HIS122
A	ASP124
A	HIS189
A	CYS208
A	HIS250

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22713171

Chain	Residue	Details
A	LYS211
A	ASN220

---