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Crystal structure of de novo designed helical repeat protein DHR18
Descriptor:	Designed helical repeat protein, PHOSPHATE ION
Authors:	Bhabha, G, Ekiert, D.C.
Deposit date:	2015-07-28
Release date:	2015-12-16
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Exploring the repeat protein universe through computational protein design. Nature, 528, 2015

6VKN

BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Cottrell, C.A, Ward, A.B.
Deposit date:	2020-01-21
Release date:	2020-08-12
Last modified:	2024-11-06
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020

4JPJ

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6
Authors:	Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A.
Deposit date:	2013-03-19
Release date:	2013-04-10
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

3IIO

Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series
Descriptor:	KE07
Authors:	Khersonsky, O, Dym, O, Tawfik, D.S.
Deposit date:	2009-08-03
Release date:	2010-03-02
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series. J.Mol.Biol., 396, 2010

5FK9

Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor
Descriptor:	ENTEROTOXIN TYPE A, T CELL RECEPTOR ALPHA CHAIN, T CELL RECEPTOR BETA CHAIN
Authors:	Rodstrom, K.E.J, Regenthal, P, Lindkvist-Petersson, K.
Deposit date:	2015-10-15
Release date:	2016-05-25
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Two Common Structural Motifs for Tcr Recognition by Staphylococcal Enterotoxins Sci.Rep., 6, 2016

6VL5

BG505 SOSIP reconstructed from a designed tetrahedral nanoparticle, BG505 SOSIP-T33_dn2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.v5.2(7S) - gp120, ...
Authors:	Ward, A.B, Antanasijevic, A.
Deposit date:	2020-01-22
Release date:	2020-08-12
Last modified:	2024-11-20
Method:	ELECTRON MICROSCOPY (4.5 Å)
Cite:	Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020

4JPI

Crystal structure of a putative VRC01 germline precursor Fab
Descriptor:	GLYCEROL, Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain
Authors:	Julien, J.-P, Diwanji, D.C, Jardine, J, Schief, W.R, Wilson, I.A.
Deposit date:	2013-03-19
Release date:	2013-04-10
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

4JPK

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ...
Authors:	Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A.
Deposit date:	2013-03-19
Release date:	2013-04-10
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

5FKA

Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor
Descriptor:	STAPHYLOCOCCAL ENTEROTOXIN E, T CELL RECEPTOR ALPHA CHAIN, T CELL RECEPTOR BETA CHAIN, ...
Authors:	Rodstrom, K.E.J, Regenthal, P, Lindkvist-Petersson, K.
Deposit date:	2015-10-15
Release date:	2016-05-25
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Two Common Structural Motifs for Tcr Recognition by Staphylococcal Enterotoxins. Sci.Rep., 6, 2016

6VL6

De novo designed tetrahedral nanoparticle T33_dn2 presenting BG505 SOSIP trimers
Descriptor:	T33_dn2A, T33_dn2B
Authors:	Ward, A.B, Antanasijevic, A.
Deposit date:	2020-01-22
Release date:	2020-08-12
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4.6 Å)
Cite:	Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020

3IIP

Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series
Descriptor:	KE7 R6 3/7F, POLYETHYLENE GLYCOL (N=34)
Authors:	Khersonsky, O, Dym, O, Tawfik, D.S.
Deposit date:	2009-08-03
Release date:	2010-03-02
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series. J.Mol.Biol., 396, 2010

2AR1

Structure of Hypothetical protein from Leishmania major
Descriptor:	GLYCEROL, hypothetical protein
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-08-18
Release date:	2005-08-30
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.602 Å)
Cite:	Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallogr.,Sect.F, 62, 2006

5VID

Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.0671.2
Descriptor:	Bot.0671.2, Botulinum neurotoxin type B
Authors:	Jin, R, Lam, K, Yao, G.
Deposit date:	2017-04-15
Release date:	2017-09-20
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

5WOD

De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures
Descriptor:	38-mer peptide
Authors:	Wu, H, Wu, Y, DeGrado, W.F.
Deposit date:	2017-08-01
Release date:	2017-10-04
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5VMR

Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.2110.4
Descriptor:	Bot.2110.4, Botulinum neurotoxin type B
Authors:	Jin, R, Lam, K, Yao, G.
Deposit date:	2017-04-28
Release date:	2017-09-20
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

5VLI

Computationally designed inhibitor peptide HB1.6928.2.3 in complex with influenza hemagglutinin (A/PuertoRico/8/1934)
Descriptor:	2,5,8,11-TETRAOXATRIDECANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Bernard, S.M, Wilson, I.A.
Deposit date:	2017-04-25
Release date:	2017-09-27
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.799 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

5WOC

De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures
Descriptor:	(3-methylphenyl)methanol, SER-PRO-GLU-GLU-ARG-ALA-GLN-LEU-CYS-THR-ALA-ALA-GLU-LYS-ALA-ASP-GLU-LEU-GLY
Authors:	Wu, H, Wu, Y, DeGrado, W.F.
Deposit date:	2017-08-01
Release date:	2017-10-04
Last modified:	2024-10-30
Method:	SOLUTION NMR
Cite:	De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

7LDF

High resolution NMR solution structure of a de novo designed minimal thioredoxin fold protein
Descriptor:	Minimal thioredoxin fold protein, ems_thioM_802
Authors:	Urbauer, J.L, Strauch, E.M.
Deposit date:	2021-01-13
Release date:	2022-07-13
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Sampling of structure and sequence space of small protein folds. Nat Commun, 13, 2022

2Y92

Crystal structure of MAL adaptor protein
Descriptor:	2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN,
Authors:	Valkov, E, Stamp, A, Martin, J.L, Kobe, B.
Deposit date:	2011-02-11
Release date:	2011-09-14
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (3.01 Å)
Cite:	Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection. Proc.Natl.Acad.Sci.USA, 108, 2011

7L8F

BG505 SOSIP.v5.2(7S) in complex with the polyclonal Fab pAbC-2 from animal Rh.33172 (Wk38 time point)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:	Antanasijevic, A, Sewall, L.M, Ward, A.B.
Deposit date:	2020-12-31
Release date:	2021-08-04
Last modified:	2024-10-23
Method:	ELECTRON MICROSCOPY (3.66 Å)
Cite:	Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nat Commun, 12, 2021

7KBQ

Solution NMR Structure of DE NOVO DESIGNED Rossmann 3x3 Fold Protein r3x3_bp3, Northeast Structural Genomics Consortium (NESG) Target OR689
Descriptor:	DE NOVO DESIGNED OR689
Authors:	Liu, G, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:	2020-10-02
Release date:	2021-05-19
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Role of backbone strain in de novo design of complex alpha/beta protein structures Accurate de novo design of asymetric alpha/beta proteins with ten or more secondary structure elements requires consideration of backbone strain Design principle proposed from designed larger alpha/beta-proteins not folded as designed: Consistency between local, non-local, and global structures To Be Published

2GJF

NMR structure of the computationally designed procarboxypeptidase-A (1AYE) domain
Descriptor:	DESIGNED PROTEIN
Authors:	Reichow, S.
Deposit date:	2006-03-30
Release date:	2007-01-16
Last modified:	2024-05-29
Method:	SOLUTION NMR
Cite:	High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J.Mol.Biol., 366, 2007

7L7T

BG505 SOSIP reconstructed from a designed nanoparticle, BG505 SOSIP-T33-31 (Component A)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.v5.2(7S) - gp120, ...
Authors:	Antanasijevic, A, Cannac, F, Sewall, L.M, Ward, A.B.
Deposit date:	2020-12-30
Release date:	2021-08-04
Last modified:	2024-11-20
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nat Commun, 12, 2021

7L8C

BG505 SOSIP MD39 in complex with the polyclonal Fab pAbC-3 from animal Rh.33104 (Wk26 time point)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP MD39 - gp120, ...
Authors:	Antanasijevic, A, Sewall, L.M, Perrett, H.R, Ward, A.B.
Deposit date:	2020-12-31
Release date:	2021-08-04
Last modified:	2024-11-20
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nat Commun, 12, 2021

7L8Y

BG505 SOSIP.v5.2 N241/N289 in complex with the polyclonal Fab pAbC-5 from animal Rh.33311 (Wk26 time point)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.v5.2 N241/N289 - gp120, ...
Authors:	Antanasijevic, A, Sewall, L.M, Cannac, F, Ward, A.B.
Deposit date:	2021-01-01
Release date:	2021-08-04
Last modified:	2024-11-20
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nat Commun, 12, 2021

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Total results:	818
Displayed results:	25
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