7LLA
 
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7LIW
 | | Local refinement of human ATP citrate lyase E599Q mutant ASH domain | | Descriptor: | (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-01-28 | | Release date: | 2021-05-19 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021
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8G1F
 | | Structure of ACLY-D1026A-products | | Descriptor: | (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2023-02-02 | | Release date: | 2023-05-10 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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8G1E
 | | Structure of ACLY-D1026A-products-asym | | Descriptor: | (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2023-02-02 | | Release date: | 2023-05-10 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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8G5D
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8GIX
 | | Chaetomium thermophilum Hir3 | | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, Histone transcription regulator 3 homolog | | Authors: | Szurgot, M.R, van Eeuwen, T, Kim, H.J, Marmorstein, R. | | Deposit date: | 2023-03-14 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the Hir histone chaperone complex.
Mol.Cell, 2024
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4U9W
 | | Crystal Structure of NatD bound to H4/H2A peptide and CoA | | Descriptor: | COENZYME A, GLYCEROL, Histone H4/H2A N-terminus, ... | | Authors: | Magin, R.S, Liszczak, G.P, Marmorstein, R. | | Deposit date: | 2014-08-06 | | Release date: | 2015-01-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | The Molecular Basis for Histone H4- and H2A-Specific Amino-Terminal Acetylation by NatD.
Structure, 23, 2015
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4U9V
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4UA3
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5WI2
 | | Crystal structure of the KA1 domain from human Chk1 | | Descriptor: | ACETATE ION, GLYCEROL, cDNA FLJ56409, ... | | Authors: | Emptage, R.P, Marmorstein, R. | | Deposit date: | 2017-07-18 | | Release date: | 2017-10-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase-associated 1 domain.
J. Biol. Chem., 292, 2017
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1AOZ
 | | REFINED CRYSTAL STRUCTURE OF ASCORBATE OXIDASE AT 1.9 ANGSTROMS RESOLUTION | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ASCORBATE OXIDASE, COPPER (II) ION, ... | | Authors: | Messerschmidt, A, Ladenstein, R, Huber, R. | | Deposit date: | 1992-01-08 | | Release date: | 1993-10-31 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Refined crystal structure of ascorbate oxidase at 1.9 A resolution.
J.Mol.Biol., 224, 1992
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6UIA
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2YAK
 | | Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) | | Descriptor: | DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4 | | Authors: | Feng, L, Geisselbrecht, Y, Blanck, S, Wilbuer, A, Atilla-Gokcumen, G.E, Filippakopoulos, P, Kraeling, K, Celik, M.A, Harms, K, Maksimoska, J, Marmorstein, R, Frenking, G, Knapp, S, Essen, L.-O, Meggers, E. | | Deposit date: | 2011-02-23 | | Release date: | 2011-04-27 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors.
J.Am.Chem.Soc., 133, 2011
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1B16
 | | ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS TERNARY COMPLEX WITH NAD-3-PENTANONE | | Descriptor: | NICOTINAMIDE ADENINE DINUCLEOTIDE 3-PENTANONE ADDUCT, PROTEIN (ALCOHOL DEHYDROGENASE) | | Authors: | Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. | | Deposit date: | 1998-11-25 | | Release date: | 1999-11-29 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.
J.Mol.Biol., 289, 1999
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1B15
 | | ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS TERNARY COMPLEX WITH NAD-ACETONE | | Descriptor: | ALCOHOL DEHYDROGENASE, NICOTINAMIDE ADENINE DINUCLEOTIDE ACETONE ADDUCT | | Authors: | Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. | | Deposit date: | 1998-11-25 | | Release date: | 1999-11-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.
J.Mol.Biol., 289, 1999
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1B2L
 | | ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS: TERNARY COMPLEX WITH NAD-CYCLOHEXANONE | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ALCOHOL DEHYDROGENASE, CALCIUM ION, ... | | Authors: | Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. | | Deposit date: | 1998-11-26 | | Release date: | 1999-11-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.
J.Mol.Biol., 289, 1999
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1TYO
 | | Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix in complex with etheno-NADP | | Descriptor: | ETHENO-NADP, isocitrate dehydrogenase | | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N, Ladenstein, R. | | Deposit date: | 2004-07-08 | | Release date: | 2005-07-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
J.Mol.Biol., 345, 2005
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1TRO
 | | CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION | | Descriptor: | DNA (5'-D(*TP*GP*TP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*TP*AP*GP*T P*AP*C)-3'), PROTEIN (TRP REPRESSOR), TRYPTOPHAN | | Authors: | Otwinowski, Z, Schevitz, R.W, Zhang, R.-G, Lawson, C.L, Joachimiak, A, Marmorstein, R, Luisi, B.F, Sigler, P.B. | | Deposit date: | 1992-08-30 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of trp repressor/operator complex at atomic resolution.
Nature, 335, 1988
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1GP1
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1A4U
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4MHX
 | | Crystal Structure of Sulfamidase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Sidhu, N.S, Uson, I, Schreiber, K, Proepper, K, Becker, S, Gaertner, J, Kraetzner, R, Steinfeld, R, Sheldrick, G.M. | | Deposit date: | 2013-08-30 | | Release date: | 2014-05-14 | | Last modified: | 2021-06-02 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
Acta Crystallogr.,Sect.D, 70, 2014
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1XGV
 | | Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix | | Descriptor: | Isocitrate dehydrogenase | | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R. | | Deposit date: | 2004-09-17 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
J.Mol.Biol., 345, 2005
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1XKD
 | | Ternary complex of Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix | | Descriptor: | CALCIUM ION, ISOCITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R. | | Deposit date: | 2004-09-28 | | Release date: | 2005-10-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability.
J.Mol.Biol., 345, 2005
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1QP9
 | | STRUCTURE OF HAP1-PC7 COMPLEXED TO THE UAS OF CYC7 | | Descriptor: | CYP1(HAP1-PC7) ACTIVATORY PROTEIN, DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3'), ... | | Authors: | Lukens, A, King, D, Marmorstein, R. | | Deposit date: | 1999-06-01 | | Release date: | 2000-10-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation.
Nucleic Acids Res., 28, 2000
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6O07
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