6FF4
 
 | | human Bact spliceosome core structure | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | Authors: | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | | Deposit date: | 2018-01-03 | | Release date: | 2018-08-29 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
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8Q7N
 | | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | | Deposit date: | 2023-08-16 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
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1ZAW
 | | Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form A | | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | | Deposit date: | 2005-04-07 | | Release date: | 2005-07-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation.
Cell(Cambridge,Mass.), 121, 2005
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1ZAV
 | | Ribosomal Protein L10-L12(NTD) Complex, Space Group P21 | | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | | Deposit date: | 2005-04-07 | | Release date: | 2005-07-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation.
Cell(Cambridge,Mass.), 121, 2005
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6Z9F
 | | 1.56 A structure of human apoferritin obtained from data subset of Titan Mono-BCOR microscope | | Descriptor: | Ferritin heavy chain, SODIUM ION | | Authors: | Yip, K.M, Fischer, N, Paknia, E, Chari, A, Stark, H. | | Deposit date: | 2020-06-03 | | Release date: | 2020-06-24 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (1.56 Å) | | Cite: | Atomic-resolution protein structure determination by cryo-EM.
Nature, 587, 2020
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6Z6U
 | | 1.25 A structure of human apoferritin obtained from Titan Mono-BCOR microscope | | Descriptor: | Ferritin heavy chain, MAGNESIUM ION, SODIUM ION | | Authors: | Yip, K.M, Fischer, N, Paknia, E, Chari, A, Stark, H. | | Deposit date: | 2020-05-29 | | Release date: | 2020-06-24 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (1.25 Å) | | Cite: | Atomic-resolution protein structure determination by cryo-EM.
Nature, 587, 2020
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6Z9E
 | | 1.55 A structure of human apoferritin obtained from data subset of Titan Mono-BCOR microscope | | Descriptor: | Ferritin heavy chain, SODIUM ION | | Authors: | Yip, K.M, Fischer, N, Paknia, E, Chari, A, Stark, H. | | Deposit date: | 2020-06-03 | | Release date: | 2020-06-24 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (1.55 Å) | | Cite: | Atomic-resolution protein structure determination by cryo-EM.
Nature, 587, 2020
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5LZA
 | | Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. | | Deposit date: | 2016-09-29 | | Release date: | 2016-11-23 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
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5LZF
 | | Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. | | Deposit date: | 2016-09-29 | | Release date: | 2016-11-23 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
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1ZAX
 | | Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B | | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | | Deposit date: | 2005-04-07 | | Release date: | 2005-07-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation.
Cell(Cambridge,Mass.), 121, 2005
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7A6B
 | | 1.33 A structure of human apoferritin obtained from Titan Mono- BCOR microscope | | Descriptor: | Ferritin heavy chain, SODIUM ION | | Authors: | Yip, K.M, Fischer, N, Chari, A, Stark, H. | | Deposit date: | 2020-08-25 | | Release date: | 2020-09-02 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (1.33 Å) | | Cite: | Atomic-resolution protein structure determination by cryo-EM.
Nature, 587, 2020
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7A6A
 | | 1.15 A structure of human apoferritin obtained from Titan Mono- BCOR microscope | | Descriptor: | Ferritin heavy chain, SODIUM ION | | Authors: | Yip, K.M, Fischer, N, Chari, A, Stark, H. | | Deposit date: | 2020-08-25 | | Release date: | 2020-09-02 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (1.15 Å) | | Cite: | Atomic-resolution protein structure determination by cryo-EM.
Nature, 587, 2020
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6QL5
 | | Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom | | Descriptor: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | Deposit date: | 2019-01-31 | | Release date: | 2020-03-18 | | Last modified: | 2020-04-08 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6QL6
 | | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | | Descriptor: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | Deposit date: | 2019-01-31 | | Release date: | 2020-03-18 | | Last modified: | 2020-04-08 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6QL7
 | | Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom | | Descriptor: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17 | | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | Deposit date: | 2019-01-31 | | Release date: | 2020-03-18 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (4.6 Å) | | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6QL9
 | | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | | Descriptor: | 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ... | | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | | Deposit date: | 2019-01-31 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
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6H60
 | | pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex | | Descriptor: | Pyruvate dehydrogenase protein X component, mitochondrial | | Authors: | Haselbach, D, Prajapati, S, Tittmann, K, Stark, H. | | Deposit date: | 2018-07-25 | | Release date: | 2019-06-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
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6H55
 | | core of the human pyruvate dehydrogenase (E2) | | Descriptor: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | | Authors: | Haselbach, D, Prajapati, S, Tittmann, K, Stark, H. | | Deposit date: | 2018-07-23 | | Release date: | 2019-06-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
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5MRD
 | | Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Arencibia, J.M, Froehner, W, Krupa, M, Pastor-Flores, D, Merker, P, Oellerich, T, Neimanis, S, Schmithals, C, Koeberle, V, Suess, E, Zeuzem, S, Stark, H, Piiper, A, Odadzic, D, Schulze, J.O, Biondi, R.M. | | Deposit date: | 2016-12-22 | | Release date: | 2017-01-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
ACS Chem. Biol., 12, 2017
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8PSG
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the acetyl transferase domain (FASx sample) | | Descriptor: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-13 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSP
 | | Asymmetric unit of the yeast fatty acid synthase in rotated state with ACP at the acetyl transferase domain (FASx sample) | | Descriptor: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-13 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSJ
 | | Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl transferase domain (FASx sample) | | Descriptor: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-13 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSA
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASam sample) | | Descriptor: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-13 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PRW
 | | Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution | | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, COENZYME A, Fatty acid synthase subunit alpha, ... | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-12 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (1.9 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PS9
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASam sample) | | Descriptor: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | | Authors: | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | Deposit date: | 2023-07-13 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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