8J5Z
 
 | | The cryo-EM structure of the TwOSC1 tetramer | | Descriptor: | Terpene cyclase/mutase family member, octyl beta-D-glucopyranoside | | Authors: | Ma, X, Yuru, T, Yunfeng, L, Jiang, T. | | Deposit date: | 2023-04-24 | | Release date: | 2023-11-01 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (4.75 Å) | | Cite: | Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8GZ2
 | | Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | | Descriptor: | (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... | | Authors: | Li, Y, Jiang, D. | | Deposit date: | 2022-09-24 | | Release date: | 2023-03-08 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.
Nat Commun, 14, 2023
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8GZ1
 | | Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | | Authors: | Li, Y, Jiang, D. | | Deposit date: | 2022-09-24 | | Release date: | 2023-03-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.
Nat Commun, 14, 2023
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8X4Q
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8X4S
 | | The L-tryptophan specific decarboxylase PsiD covalent bonding with tryptamine | | Descriptor: | (2~{R})-2-[2-(1~{H}-indol-3-yl)ethylamino]propanoic acid, L-tryptophan decarboxylase | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2023-11-15 | | Release date: | 2024-11-20 | | Last modified: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIG
 | | Crystal structure of the methyltransferase PsiM in complex with s-adenosylmethionine (SAM) | | Descriptor: | Psilocybin synthase, S-ADENOSYLMETHIONINE | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-13 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIO
 | | Crystal structure of the methyltransferase PsiM in complex with SAH and Psilocybin | | Descriptor: | GLYCEROL, Psilocybin, Psilocybin synthase, ... | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIH
 | | Crystal structure of the methyltransferase PsiM in complex with SAH | | Descriptor: | Psilocybin synthase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZII
 | | Crystal structure of the methyltransferase PsiM in complex with SAH and Norbaeocystin | | Descriptor: | Norbaeocystin, Psilocybin synthase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIC
 | | Structure complex of 4-hydroxytryptamine kinase PsiK complexed with Mg2+ and Tryptamine | | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, 4-hydroxytryptamine kinase, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-13 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIM
 | | Crystal structure of the methyltransferase PsiM in complex with SAH and Baeocystin | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Baeocystin, GLYCEROL, ... | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIA
 | | The L-tryptophan specific decarboxylase PsiD(50-439) in complex with tryptamine | | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, L-tryptophan decarboxylase | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-13 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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8ZIE
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8YMB
 | | The crystal structure of SHD931 in complex with Brd4-BD2 and VCB | | Descriptor: | Bromodomain-containing protein 4, CHLORIDE ION, Elongin-B, ... | | Authors: | Huang, W.X, Chen, Y.H, Li, C.G, Ding, K. | | Deposit date: | 2024-03-08 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure-Based Design of "Head-to-Tail" Macrocyclic PROTACs.
Jacs Au, 4, 2024
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8Y7L
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1ML7
 | | Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole | | Descriptor: | 4-IODOPYRAZOLE, 5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC ACID FERROUS COMPLEX, nitrophorin 4 | | Authors: | Berry, R.E, Ding, X.D, Weichsel, A, Montfort, W.R, Walker, F.A. | | Deposit date: | 2002-08-30 | | Release date: | 2002-09-20 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4
J.Biol.Inorg.Chem., 9, 2004
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3FLL
 | | Crystal structure of E55Q mutant of nitrophorin 4 | | Descriptor: | AMMONIA, Nitrophorin-4, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Montfort, W.R, Weichsel, A. | | Deposit date: | 2008-12-18 | | Release date: | 2009-02-10 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes.
J.Am.Chem.Soc., 131, 2009
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4RO1
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1PEE
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