8GZ2

Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin

Summary for 8GZ2

• Entry DOI: 10.2210/pdb8gz2/pdb
• EMDB information: 34388
• Descriptor: Sodium channel subunit beta-1, Sodium channel protein type 8 subunit alpha, Sodium channel subunit beta-2, ... (6 entities in total)
• Functional Keywords: ion channal, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 278284.96

Authors

Li, Y.,Jiang, D. (deposition date: 2022-09-24, release date: 2023-03-08)

• Primary citation: Li, Y.,Yuan, T.,Huang, B.,Zhou, F.,Peng, C.,Li, X.,Qiu, Y.,Yang, B.,Zhao, Y.,Huang, Z.,Jiang, D.; Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.; Nat Commun, 14:1030-1030, 2023; PubMed: 36823201; DOI: 10.1038/s41467-023-36766-9

Experimental method

ELECTRON MICROSCOPY (3.3 Å)