8GZ2

Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	Sodium channel subunit beta-1	polymer	218	24732.1	1	UniProt (Q07699) Pfam (PF07686)	Homo sapiens (human)
2	B (B)	Sodium channel protein type 8 subunit alpha	polymer	1980	225520.6	1	UniProt (Q9UQD0) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF24609)	Homo sapiens (human)	Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6
3	C (C)	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686)	Homo sapiens (human)
4	D, E, F, G, H (A, E, F, G, H)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	5	In PDB GlyTouCan (G15407YE)
5	I, J (D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	K (B)	(1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name)	non-polymer		301.3	1	Chemie (WMK) PubChem (23350328) PubChem (25199634) PubChem (59509171) PubChem (13992062) PubChem (107878) PubChem (101758149) PubChem (11507706) PubChem (10286310) PubChem (124201860) PubChem (11243537) PubChem (11500416) PubChem (11536757) PubChem (13992063) PubChem (13992064) PubChem (13992067) PubChem (13992068) PubChem (146156897) PubChem (171761687) PubChem (163189502) PubChem (166636640) PubChem (175613399)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	274608.6
Branched	Number of molecules	5
	Total formula weight	2932.7
Non-Polymers*	Number of molecules	3
	Total formula weight	743.7
All*	Total formula weight	278285.0

*Water molecules are not included.