8Y7L

Crystal Structure of Nur77 LBD in complex with N-(2'-(4-hydroxypiperidin-1-yl)-[4,4'-bipyridin]-2-yl)cinnamamide

This is a non-PDB format compatible entry.

Summary for 8Y7L

• Entry DOI: 10.2210/pdb8y7l/pdb
• Descriptor: Nuclear receptor subfamily 4immunitygroup A member 1, (~{E})-~{N}-[4-[2-(4-oxidanylpiperidin-1-yl)pyridin-4-yl]pyridin-2-yl]-3-phenyl-prop-2-enamide (3 entities in total)
• Functional Keywords: complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 53410.08

Authors

Hong, W.B.,Lin, T.W. (deposition date: 2024-02-04, release date: 2024-07-24)

• Primary citation: Chen, J.,Zhao, T.,Hong, W.,Li, H.,Ao, M.,Zhong, Y.,Chen, X.,Qiu, Y.,Wang, X.,Wu, Z.,Lin, T.,Li, B.,Chen, X.,Fang, M.; Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy; Acta Pharm Sin B, 2024; DOI: 10.1016/j.apsb.2024.07.012

Experimental method

X-RAY DIFFRACTION (2.683 Å)