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8C2D
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BU of 8c2d by Molmil
14-3-3 in complex with Pyrin pS208
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide
Authors:Lau, R, Ottmann, C, Hann, M.
Deposit date:2022-12-22
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure and ligandability of the 14-3-3/pyrin interface.
Biochem.Biophys.Res.Commun., 651, 2023
8C04
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BU of 8c04 by Molmil
Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354)
Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-15
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA
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BU of 8bza by Molmil
single soak stabilizer for ERa - 14-3-3 interaction (AZ555)
Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYO
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BU of 8byo by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2023-01-18
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0
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BU of 8bz0 by Molmil
single soak stabilizer for ERa - 14-3-3 interaction (AZ275)
Descriptor: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F
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BU of 8c4f by Molmil
Small molecule amidine soak in 14-3-3/ERa (AZ037)
Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2023-01-03
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY
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BU of 8byy by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BZW
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BU of 8bzw by Molmil
Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210)
Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-15
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G
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BU of 8c4g by Molmil
Small molecule amidine soak in 14-3-3/ERa (AZ132)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2023-01-03
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BZB
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BU of 8bzb by Molmil
co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275)
Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K
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BU of 8c0k by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-17
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYZ
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BU of 8byz by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210)
Descriptor: 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ9
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BU of 8bz9 by Molmil
single soak stabilizer for ERa - 14-3-3 interaction (AZ354)
Descriptor: 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-08-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
1O9E
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BU of 1o9e by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9F
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BU of 1o9f by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9D
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BU of 1o9d by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9C
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BU of 1o9c by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
4JC3
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BU of 4jc3 by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION
Authors:Bier, D, Ottmann, C.
Deposit date:2013-02-21
Release date:2013-05-15
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JDD
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BU of 4jdd by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN
Authors:Bier, D, Ottmann, C.
Deposit date:2013-02-25
Release date:2013-05-15
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4IHL
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BU of 4ihl by Molmil
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Descriptor: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-19
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4IEA
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BU of 4iea by Molmil
14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide
Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-13
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4OC7
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BU of 4oc7 by Molmil
Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2
Descriptor: (2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
Authors:Leysen, S, Scheepstra, M, Brunsveld, L, Milroy, L.G, Ottmann, C.
Deposit date:2014-01-08
Release date:2014-10-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A natural-product switch for a dynamic protein interface.
Angew.Chem.Int.Ed.Engl., 53, 2014
4QLI
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BU of 4qli by Molmil
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
7PWZ
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BU of 7pwz by Molmil
Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228
Descriptor: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ...
Authors:Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C.
Deposit date:2021-10-07
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
7PWT
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BU of 7pwt by Molmil
Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228
Descriptor: (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ...
Authors:Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C.
Deposit date:2021-10-07
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J.Med.Chem., 65, 2022

221051

数据于2024-06-12公开中

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