6TZO
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![BU of 6tzo by Molmil](/molmil-images/mine/6tzo) | Crystal Structure of Fungal RNA Kinase | Descriptor: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, tRNA ligase | Authors: | Shuman, S, Goldgur, Y, Banerjee, A. | Deposit date: | 2019-08-12 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor. Nucleic Acids Res., 47, 2019
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6MGN
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![BU of 6mgn by Molmil](/molmil-images/mine/6mgn) | mouse Id1 (51-104) - human hE47 (348-399) complex | Descriptor: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | Authors: | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | Deposit date: | 2018-09-14 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
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6MGM
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![BU of 6mgm by Molmil](/molmil-images/mine/6mgm) | |
6C34
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![BU of 6c34 by Molmil](/molmil-images/mine/6c34) | Mycobacterium smegmatis DNA flap endonuclease mutant D125N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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6C36
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![BU of 6c36 by Molmil](/molmil-images/mine/6c36) | Mycobacterium smegmatis flap endonuclease mutant D208N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION, PHOSPHATE ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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6C33
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![BU of 6c33 by Molmil](/molmil-images/mine/6c33) | Mycobacterium smegmatis DNA flap endonuclease | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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6C35
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![BU of 6c35 by Molmil](/molmil-images/mine/6c35) | Mycobacterium smegmatis flap endonuclease mutant D148N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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4JZC
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![BU of 4jzc by Molmil](/molmil-images/mine/4jzc) | Angiopoietin-2 fibrinogen domain TAG mutant | Descriptor: | Angiopoietin-2 | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-02 | Release date: | 2013-05-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4K0V
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![BU of 4k0v by Molmil](/molmil-images/mine/4k0v) | Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, TEK tyrosine kinase variant | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-04-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.51 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JYO
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![BU of 4jyo by Molmil](/molmil-images/mine/4jyo) | Structural basis for angiopoietin-1 mediated signaling initiation | Descriptor: | Angiopoietin-1, CALCIUM ION | Authors: | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | Deposit date: | 2013-03-31 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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5COV
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![BU of 5cov by Molmil](/molmil-images/mine/5cov) | |
5CMA
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![BU of 5cma by Molmil](/molmil-images/mine/5cma) | Anti-B7-H3 monoclonal antibody ch8H9 Fab fragment | Descriptor: | Antibody ch8H9 Fab heavy chain, Antibody ch8H9 Fab light chain | Authors: | Ahmed, M, Goldgur, Y, Cheng, M, Cheung, N.K. | Deposit date: | 2015-07-16 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3. J.Biol.Chem., 290, 2015
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5COU
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![BU of 5cou by Molmil](/molmil-images/mine/5cou) | |
5COT
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![BU of 5cot by Molmil](/molmil-images/mine/5cot) | |
6N0T
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![BU of 6n0t by Molmil](/molmil-images/mine/6n0t) | tRNA ligase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Banerjee, A, Goldgur, Y, Shuman, S. | Deposit date: | 2018-11-07 | Release date: | 2019-01-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.511 Å) | Cite: | Structure and two-metal mechanism of fungal tRNA ligase. Nucleic Acids Res., 47, 2019
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6N0V
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![BU of 6n0v by Molmil](/molmil-images/mine/6n0v) | tRNA ligase | Descriptor: | MANGANESE (II) ION, tRNA ligase | Authors: | Banerjee, A, Goldgur, Y, Shuman, S. | Deposit date: | 2018-11-07 | Release date: | 2019-01-09 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Structure and two-metal mechanism of fungal tRNA ligase. Nucleic Acids Res., 47, 2019
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6O19
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![BU of 6o19 by Molmil](/molmil-images/mine/6o19) | Crystal Structure of Pho7 complex with pho1 promoter site 2 | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*AP*TP*TP*TP*CP*CP*GP*AP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*TP*TP*AP*TP*TP*CP*GP*GP*AP*AP*AP*TP*TP*AP*AP*AP*AP*AP*CP*A)-3'), Transcription factor Pho7, ... | Authors: | Garg, A, Goldgur, Y, Shuman, S. | Deposit date: | 2019-02-18 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.596 Å) | Cite: | Structure of Fission Yeast Transcription Factor Pho7 Bound topho1Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis. Mol.Cell.Biol., 39, 2019
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6NHZ
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![BU of 6nhz by Molmil](/molmil-images/mine/6nhz) | mycobacterial DNA ligase D complexed with ATP and Mg | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase, MAGNESIUM ION | Authors: | Shuman, S, Unciuleac, M, Goldgur, Y. | Deposit date: | 2018-12-24 | Release date: | 2019-02-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. J. Biol. Chem., 294, 2019
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6NHX
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![BU of 6nhx by Molmil](/molmil-images/mine/6nhx) | mycobacterial DNA ligase D complexed with ATP and MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase | Authors: | Shuman, S, Unciuleac, M, Goldgur, Y. | Deposit date: | 2018-12-24 | Release date: | 2019-02-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. J. Biol. Chem., 294, 2019
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6TZM
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![BU of 6tzm by Molmil](/molmil-images/mine/6tzm) | Crystal Structure of Fungal RNA Kinase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, tRNA ligase | Authors: | Shuman, S, Goldgur, Y, Banerjee, A. | Deposit date: | 2019-08-12 | Release date: | 2019-11-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.714 Å) | Cite: | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor. Nucleic Acids Res., 47, 2019
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6VDD
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![BU of 6vdd by Molmil](/molmil-images/mine/6vdd) | POL domain of Pol1 from M. smegmatis complex with DNA primer-template and dNTP | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A*(DCT))-3'), DNA (5'-D(P*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | Authors: | Shuman, S, Goldgur, Y, Ghosh, S. | Deposit date: | 2019-12-24 | Release date: | 2020-02-12 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res., 48, 2020
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6VDC
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![BU of 6vdc by Molmil](/molmil-images/mine/6vdc) | POL domain of Pol1 from M. smegmatis | Descriptor: | DNA polymerase I, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Ghosh, S. | Deposit date: | 2019-12-24 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res., 48, 2020
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6VDE
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![BU of 6vde by Molmil](/molmil-images/mine/6vde) | Full-length M. smegmatis Pol1 | Descriptor: | DNA polymerase I, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Ghosh, S. | Deposit date: | 2019-12-24 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.713 Å) | Cite: | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res., 48, 2020
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6VT4
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![BU of 6vt4 by Molmil](/molmil-images/mine/6vt4) | Naegleria gruberi RNA ligase R149A mutant apo | Descriptor: | RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTE
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![BU of 6vte by Molmil](/molmil-images/mine/6vte) | Naegleria gruberi RNA Ligase K170M mutant with AMP and Mn | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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