5FBW
| PI4KB in complex with Rab11 and the MI369 Inhibitor | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... | Authors: | Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. | Deposit date: | 2015-12-14 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.487 Å) | Cite: | PI4KB in complex with Rab11 and the MI369 Inhibitor To Be Published
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8OIV
| Monkeypox virus VP39 in complex with SAH and cap0 | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Skvara, P, Chalupska, D, Silhan, J, Klima, M, Boura, E. | Deposit date: | 2023-03-23 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39. Antiviral Res., 216, 2023
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8OIX
| CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor Salinosporamid A | Descriptor: | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Family T1, proteasome alpha subunit, ... | Authors: | Silhan, J, Fajtova, P, Boura, E. | Deposit date: | 2023-03-23 | Release date: | 2024-04-10 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Tv20S proteasome in the complex with marizomib To Be Published
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8P7A
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8P0T
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8ORV
| Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203 | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, MPXVgp165 | Authors: | Duchoslav, V, Klima, M, Boura, E. | Deposit date: | 2023-04-17 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8ORW
| Crystal structure of human STING in complex with the agonist MD1203 | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon protein | Authors: | Klima, M, Boura, E. | Deposit date: | 2023-04-17 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8P45
| Crystal structure of human STING in complex with the agonist MD1202D | Descriptor: | 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein | Authors: | Klima, M, Boura, E. | Deposit date: | 2023-05-19 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8P44
| Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1202D | Descriptor: | 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, MPXVgp165 | Authors: | Duchoslav, V, Klima, M, Boura, E. | Deposit date: | 2023-05-19 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8B9N
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6FK5
| Structure of 3' phosphatase NExo (D146N) from Neisseria bound to DNA substrate in presence of magnesium ion | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), MAGNESIUM ION, ... | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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6FKE
| Structure of 3' phosphatase NExo (D146N) from Neisseria bound to product DNA hairpin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*A)-3'), Exodeoxyribonuclease III, ... | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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6FK4
| Structure of 3' phosphatase NExo (WT) from Neisseria bound to DNA substrate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*GP*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), Exodeoxyribonuclease III | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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4BTQ
| Coordinates of the bacteriophage phi6 capsid subunits fitted into the cryoEM map EMD-1206 | Descriptor: | MAJOR INNER PROTEIN P1 | Authors: | Nemecek, D, Boura, E, Wu, W, Cheng, N, Plevka, P, Qiao, J, Mindich, L, Heymann, J.B, Hurley, J.H, Steven, A.C. | Deposit date: | 2013-06-18 | Release date: | 2013-12-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Subunit Folds and Maturation Pathway of a Dsrna Virus Capsid. Structure, 21, 2013
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4BTG
| Coordinates of the bacteriophage phi6 capsid subunits (P1A and P1B) fitted into the cryoEM reconstruction of the procapsid at 4.4 A resolution | Descriptor: | MAJOR INNER PROTEIN P1 | Authors: | Nemecek, D, Boura, E, Wu, W, Cheng, N, Plevka, P, Qiao, J, Mindich, L, Heymann, J.B, Hurley, J.H, Steven, A.C. | Deposit date: | 2013-06-17 | Release date: | 2013-08-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Subunit Folds and Maturation Pathway of a Dsrna Virus Capsid. Structure, 21, 2013
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6Q69
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6Q67
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6Q68
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6QWT
| Sicinivirus 3Dpol RNA dependent RNA polymerase | Descriptor: | Genome polyprotein | Authors: | Dubankova, A, Boura, E. | Deposit date: | 2019-03-06 | Release date: | 2019-10-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation. J.Struct.Biol., 208, 2019
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6YZ1
| The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SINEFUNGIN, ZINC ION, ... | Authors: | Krafcikova, P, Silhan, J, Nencka, R, Boura, E. | Deposit date: | 2020-05-06 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. Nat Commun, 11, 2020
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7ZIU
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6HLT
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6HLV
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6HM8
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6HMV
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