6Y6K
| Cryo-EM structure of a Phenuiviridae L protein | Descriptor: | MAGNESIUM ION, RNA-dependent RNA polymerase | Authors: | Vogel, D, Thorkelsson, S.R, Quemin, E, Meier, K, Kouba, T, Gogrefe, N, Busch, C, Reindl, S, Guenther, S, Cusack, S, Gruenewald, K, Rosenthal, M. | Deposit date: | 2020-02-26 | Release date: | 2020-04-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 48, 2020
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8ERA
| RMC-5552 in complex with mTORC1 and FKBP12 | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Tomlinson, A.C.A, Yano, J.K. | Deposit date: | 2022-10-11 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
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8FOI
| Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2022-12-30 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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7KDF
| Structure of Stu2 Bound to dwarf Ndc80c | Descriptor: | NDC80 isoform 1,NDC80 isoform 1, NUF2 isoform 1,NUF2 isoform 1, SPC25 isoform 1,SPC25 isoform 1, ... | Authors: | Zahm, J.A, Stewart, M.G, Miller, M.P, Harrison, S.C. | Deposit date: | 2020-10-08 | Release date: | 2020-11-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural basis of Stu2 recruitment to yeast kinetochores. Elife, 10, 2021
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6BBS
| Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide | Descriptor: | (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, Carbonic anhydrase 2, ZINC ION | Authors: | Kovalevsky, A, Aggarwal, M, McKenna, R. | Deposit date: | 2017-10-19 | Release date: | 2018-02-28 | Last modified: | 2024-03-13 | Method: | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | Cite: | "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26, 2018
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6BCC
| Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide | Descriptor: | 6-ethoxy-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Kovalevsky, A, McKenna, R, Aggarwal, M. | Deposit date: | 2017-10-20 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION | Cite: | "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26, 2018
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6BC9
| Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide | Descriptor: | (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION | Authors: | Kovalevsky, A, McKenna, R, Aggarwal, M. | Deposit date: | 2017-10-20 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION | Cite: | "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26, 2018
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6BQ8
| Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... | Authors: | Kim, C, Kovalevsky, A, Gerlits, O. | Deposit date: | 2017-11-27 | Release date: | 2018-03-21 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | Cite: | Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator. Biochemistry, 57, 2018
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6BX8
| Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | Descriptor: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | Authors: | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | Deposit date: | 2017-12-18 | Release date: | 2019-02-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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8QI7
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8QB7
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8QBD
| Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10) | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sphingolipid long chain base-responsive protein PIL1 | Authors: | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | Deposit date: | 2023-08-24 | Release date: | 2024-07-24 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
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8QBF
| Compact state - Pil1 dimer with lipid headgroups fitted in native eisosome lattice bound to plasma membrane microdomain | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOSERINE, Sphingolipid long chain base-responsive protein PIL1 | Authors: | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | Deposit date: | 2023-08-24 | Release date: | 2024-07-24 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
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8QBG
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8QBE
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8QB8
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8S0B
| H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0F
| H. sapiens OC1M bound to double stranded DNA | Descriptor: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0A
| H. sapiens MCM2-7 hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0D
| H. sapiens MCM bound to double stranded DNA and ORC1-6 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (58-mer), DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0C
| H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | Descriptor: | DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0E
| H. sapiens OCCM bound to double stranded DNA | Descriptor: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S09
| H. sapiens MCM2-7 double hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8SUJ
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8SO0
| Cryo-EM structure of the PP2A:B55-FAM122A complex | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-04-28 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.79961 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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