6BCC
Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide
Summary for 6BCC
Entry DOI | 10.2210/pdb6bcc/pdb |
Related | 6BBS 6BC9 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ... (4 entities in total) |
Functional Keywords | protonation state, drug binding, hydrogen bonding, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29612.79 |
Authors | Kovalevsky, A.,McKenna, R.,Aggarwal, M. (deposition date: 2017-10-20, release date: 2018-02-28, Last modification date: 2023-10-04) |
Primary citation | Kovalevsky, A.,Aggarwal, M.,Velazquez, H.,Cuneo, M.J.,Blakeley, M.P.,Weiss, K.L.,Smith, J.C.,Fisher, S.Z.,McKenna, R. "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure, 26:383-390.e3, 2018 Cited by PubMed: 29429876DOI: 10.1016/j.str.2018.01.006 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report