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8GXR
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BU of 8gxr by Molmil
crystal structure of UBC domain of UBE2O
Descriptor: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O, CITRIC ACID
Authors:Fu, Z, Zhu, W, Huang, H.
Deposit date:2022-09-21
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:crystal structure of UBE2O
To Be Published
2N9B
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BU of 2n9b by Molmil
Solution NMR Structure of Antiparallel Myosin-10:GCN4 Tandem Coiled-Coil
Descriptor: Unconventional myosin-X, General control protein GCN4 fusion
Authors:Vavra, K.C, Xia, Y, Rock, R.S.
Deposit date:2015-11-12
Release date:2016-06-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection
Biophys.J., 110, 2016
4MBJ
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BU of 4mbj by Molmil
Human B-Raf Kinase Domain in Complex with an Imidazopyridine-based Inhibitor
Descriptor: 2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C.
Deposit date:2013-08-19
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.
Bioorg.Med.Chem.Lett., 23, 2013
6IX4
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BU of 6ix4 by Molmil
Structure of an epoxide hydrolase from Aspergillus usamii E001 (AuEH2) at 1.51 Angstroms resolution
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Hu, D, Hu, B.C, Hou, X.D, Wu, L, Rao, Y.J, Wu, M.C.
Deposit date:2018-12-09
Release date:2019-12-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.511 Å)
Cite:Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity.
Int.J.Biol.Macromol., 169, 2021
8JHG
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BU of 8jhg by Molmil
Native SUV420H1 bound to 167-bp nucleosome
Descriptor: DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ...
Authors:Lin, F, Li, W.
Deposit date:2023-05-23
Release date:2023-11-22
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase.
Cell Discov, 9, 2023
8JHF
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BU of 8jhf by Molmil
Native SUV420H1 bound to 167-bp nucleosome
Descriptor: DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ...
Authors:Lin, F, Li, W.
Deposit date:2023-05-23
Release date:2023-11-15
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase.
Cell Discov, 9, 2023
7CBT
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BU of 7cbt by Molmil
The crystal structure of SARS-CoV-2 main protease in complex with GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase
Authors:Shi, Y, Peng, G.
Deposit date:2020-06-13
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.346 Å)
Cite:The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10, 2021
7EN9
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BU of 7en9 by Molmil
Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-02
Descriptor: 3C-like proteinase, 5-bromanyl-~{N}-methyl-3-nitro-2-[(4~{R},5~{S})-2-(7-oxidanylisoquinolin-4-yl)carbonyl-4-phenyl-2,7-diazaspiro[4.4]nonan-7-yl]benzamide
Authors:Hou, N, Peng, C, Hu, Q.
Deposit date:2021-04-16
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Acs Cent.Sci., 9, 2023
7END
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BU of 7end by Molmil
Crystal structure of SARS-CoV 3CLpro in complex with the non-covalent inhibitor WU-04
Descriptor: Replicase polyprotein 1a, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide
Authors:Hou, N, Peng, C, Hu, Q.
Deposit date:2021-04-16
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Acs Cent.Sci., 9, 2023
7EN8
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BU of 7en8 by Molmil
Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-04
Descriptor: 3C-like proteinase, GLYCEROL, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide
Authors:Hou, N, Peng, C, Hu, Q.
Deposit date:2021-04-16
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Acs Cent.Sci., 9, 2023
7ENE
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BU of 7ene by Molmil
Crystal structure of MERS-CoV 3CLpro in complex with the non-covalent inhibitor WU-04
Descriptor: ORF1a protein, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide
Authors:Hou, N, Peng, C, Hu, Q.
Deposit date:2021-04-16
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Acs Cent.Sci., 9, 2023
7FET
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BU of 7fet by Molmil
SARS-CoV-2 B.1.1.7 Spike Glycoprotein trimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wen, Z.L, Zhu, Y, Sun, F.
Deposit date:2021-07-21
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha).
Cell Discov, 7, 2021
7FEM
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BU of 7fem by Molmil
SARS-CoV-2 B.1.1.7 S-ACE2 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Wen, Z.L, Zhu, Y, Sun, F.
Deposit date:2021-07-21
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha).
Cell Discov, 7, 2021
7WGX
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BU of 7wgx by Molmil
SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Zhu, Y, Tai, L, Yin, G, Sun, F.
Deposit date:2021-12-29
Release date:2023-01-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Cell Discov, 8, 2022
7WGV
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BU of 7wgv by Molmil
SARS-CoV-2 spike glycoprotein trimer in closed state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Zhu, Y, Tai, L, Yin, G, Sun, F.
Deposit date:2021-12-29
Release date:2023-01-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Cell Discov, 8, 2022
7WGZ
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BU of 7wgz by Molmil
SARS-CoV-2 spike glycoprotein trimer in open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhu, Y, Tai, L, Yin, G, Sun, F.
Deposit date:2021-12-29
Release date:2023-01-04
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Cell Discov, 8, 2022
7WGY
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BU of 7wgy by Molmil
SARS-CoV-2 spike glycoprotein trimer in Intermediate state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhu, Y, Tai, L, Yin, G, Sun, F.
Deposit date:2021-12-29
Release date:2023-01-04
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Cell Discov, 8, 2022
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数据于2024-06-12公开中

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