8BRO
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![BU of 8bro by Molmil](/molmil-images/mine/8bro) | Structure of the N-terminal domain of BC2L-C lectin (1-131) in complex with a synthetic beta-fucosylamide | Descriptor: | 5-[3-(aminomethyl)phenyl]-~{N}-[(2~{S},3~{S},4~{R},5~{S},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]furan-2-carboxamide, Lectin | Authors: | Varrot, A, Lunstrom, J. | Deposit date: | 2022-11-23 | Release date: | 2023-02-08 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from Burkholderia cenocepacia. Molecules, 28, 2023
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6HTN
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![BU of 6htn by Molmil](/molmil-images/mine/6htn) | Structure of a fucose lectin from Kordia zhangzhouensis in complex with methyl-fucoside | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... | Authors: | Varrot, A. | Deposit date: | 2018-10-04 | Release date: | 2019-01-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Architecture and Evolution of Blade Assembly in beta-propeller Lectins. Structure, 27, 2019
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7Z62
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![BU of 7z62 by Molmil](/molmil-images/mine/7z62) | Structure of the LecA lectin from Pseudomonas aeruginosa in complex with a biaryl-thiogalactoside | Descriptor: | (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[1-(4-methoxyphenyl)ethenyl]phenyl]sulfanyl-oxane-3,4,5-triol, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Varrot, A. | Deposit date: | 2022-03-10 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties. Eur.J.Med.Chem., 247, 2022
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7Z63
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![BU of 7z63 by Molmil](/molmil-images/mine/7z63) | |
8R8C
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![BU of 8r8c by Molmil](/molmil-images/mine/8r8c) | |
6TIG
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![BU of 6tig by Molmil](/molmil-images/mine/6tig) | Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) antigen | Descriptor: | Lectin, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose | Authors: | Varrot, A, Bermeo, R. | Deposit date: | 2019-11-22 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information. Molecules, 25, 2020
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6TID
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![BU of 6tid by Molmil](/molmil-images/mine/6tid) | |
5O7V
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![BU of 5o7v by Molmil](/molmil-images/mine/5o7v) | |
5O7W
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![BU of 5o7w by Molmil](/molmil-images/mine/5o7w) | Crystal structure of the 4-FLUORO RSL lectin in complex with Lewis x tetrasaccharide | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Putative fucose-binding lectin protein, ... | Authors: | Varrot, A. | Deposit date: | 2017-06-09 | Release date: | 2018-06-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs. ACS Chem. Biol., 13, 2018
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5O7U
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6ZU2
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![BU of 6zu2 by Molmil](/molmil-images/mine/6zu2) | CML1 crystal structure in complex with H-type 1 trisaccharide | Descriptor: | Mucin-binding lectin 1, SULFATE ION, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Varrot, A, Bleuler-Martinez, S. | Deposit date: | 2020-07-21 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity. Glycobiology, 32, 2022
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6ZV5
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![BU of 6zv5 by Molmil](/molmil-images/mine/6zv5) | CML1 crystal structure in complex with Lewis a tetrasaccharide | Descriptor: | Mucin-binding lectin 1, SULFATE ION, beta-D-galactopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Varrot, A, Bleuler-Martinez, S. | Deposit date: | 2020-07-24 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity. Glycobiology, 32, 2022
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5M1Z
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7PRP
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![BU of 7prp by Molmil](/molmil-images/mine/7prp) | |
7PRS
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1UP6
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![BU of 1up6 by Molmil](/molmil-images/mine/1up6) | Structure of the 6-phospho-beta glucosidase from Thermotoga maritima at 2.55 Angstrom resolution in the tetragonal form with manganese, NAD+ and glucose-6-phosphate | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, 6-PHOSPHO-BETA-GLUCOSIDASE, MANGANESE (II) ION, ... | Authors: | Varrot, A, Yip, V.L, Withers, S.G, Davies, G.J. | Deposit date: | 2003-09-29 | Release date: | 2004-08-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | An Unusual Mechanism of Glycoside Hydrolysis Involving Redox and Elimination Steps by a Family 4 Beta-Glycosidase from Thermotoga Maritima. J.Am.Chem.Soc., 126, 2004
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2W4S
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![BU of 2w4s by Molmil](/molmil-images/mine/2w4s) | novel RNA-binding domain in Cryptosporidium parvum at 2.5 angstrom resolution | Descriptor: | Ankyrin-repeat protein | Authors: | Varrot, A, Mackereth, C, Mourao, A, Sattler, M, Cusack, S. | Deposit date: | 2008-12-02 | Release date: | 2009-12-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure and RNA Recognition by the Snrna and Snorna Transport Factor Phax. RNA, 16, 2010
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4UT5
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![BU of 4ut5 by Molmil](/molmil-images/mine/4ut5) | Crystal structure of the LecB lectin from Pseudomonas aeruginosa strain PA7 in complex with lewis a tetrasaccharide | Descriptor: | CALCIUM ION, LECB LECTIN, beta-D-galactopyranose, ... | Authors: | Boukerb, A.M, Decor, A, Tabaroni, R, Varrot, A, Debentzmann, S, Vidal, S, Imberty, A, Cournoyer, B. | Deposit date: | 2014-07-18 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Genomic Rearrangements and Functional Diversification of Leca and Lecb Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed Against Pseudomonas Aeruginosa. Front.Microbiol., 7, 2016
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7R55
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![BU of 7r55 by Molmil](/molmil-images/mine/7r55) | B-trefoil lectin from Salpingoeca rosetta in complex with Gb3 | Descriptor: | 1,2-ETHANEDIOL, Sarol-1, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Notova, S, Varrot, A. | Deposit date: | 2022-02-10 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3. Commun Biol, 5, 2022
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8GUV
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![BU of 8guv by Molmil](/molmil-images/mine/8guv) | LecA from Pseudomonas aeruginosa in complex with tolcapone (CAS: 134308-13-7) | Descriptor: | CALCIUM ION, PA-I galactophilic lectin, Tolcapone | Authors: | Kuhaudomlarp, S, Siebs, E, Varrot, A, Imberty, A, Titz, A. | Deposit date: | 2022-09-13 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | LecA from Pseudomonas aeruginosa in complex with tolcapone (CAS: 134308-13-7) To Be Published
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4I6S
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![BU of 4i6s by Molmil](/molmil-images/mine/4i6s) | Structure of RSL mutant W76A in complex with L-fucose | Descriptor: | 1,2-ETHANEDIOL, Putative fucose-binding lectin protein, TETRAETHYLENE GLYCOL, ... | Authors: | Audfray, A, Arnaud, J, Varrot, A, Imberty, A. | Deposit date: | 2012-11-30 | Release date: | 2013-07-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Reduction of lectin valency drastically changes glycolipid dynamics in membranes but not surface avidity Acs Chem.Biol., 8, 2013
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4UP4
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![BU of 4up4 by Molmil](/molmil-images/mine/4up4) | Structure of the recombinant lectin PVL from Psathyrella velutina in complex with GlcNAcb-D-1,3Galactoside | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... | Authors: | Audfray, A, Beljoudi, M, Hurbin, A, Varrot, A, Breiman, A, Busser, B, Lependu, J, Coll, J.L, Imberty, A. | Deposit date: | 2014-06-12 | Release date: | 2015-01-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells. Plos One, 10, 2015
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6A3H
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![BU of 6a3h by Molmil](/molmil-images/mine/6a3h) | 2-DEOXY-2-FLURO-B-D-CELLOTRIOSYL/ENZYME INTERMEDIATE COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHEARANS AT 1.6 ANGSTROM RESOLUTION | Descriptor: | ENDOGLUCANASE, GLYCEROL, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose | Authors: | Davies, G.J, Varrot, A, Dauter, M, Brzozowski, A.M, Schulein, M, Mackenzie, L, Withers, S.G. | Deposit date: | 1998-07-22 | Release date: | 1999-07-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase. Biochemistry, 37, 1998
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6TRV
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4UOU
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![BU of 4uou by Molmil](/molmil-images/mine/4uou) | Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) - apo-form | Descriptor: | DI(HYDROXYETHYL)ETHER, FUCOSE-SPECIFIC LECTIN FLEA | Authors: | Houser, J, Komarek, J, Cioci, G, Varrot, A, Imberty, A, Wimmerova, M. | Deposit date: | 2014-06-10 | Release date: | 2015-03-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insights Into Aspergillus Fumigatus Lectin Specificity: Afl Binding Sites are Functionally Non-Equivalent. Acta Crystallogr.,Sect.D, 71, 2015
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