7Z63

Structure of the LecA lectin from Pseudomonas aeruginosa in complex with a biaryl-thiogalactoside

This is a non-PDB format compatible entry.

Summary for 7Z63

• Entry DOI: 10.2210/pdb7z63/pdb
• Descriptor: PA-I galactophilic lectin, CALCIUM ION, [3-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanyl-4-methoxy-phenyl]-(3,4,5-trimethoxyphenyl)methanone, ... (5 entities in total)
• Functional Keywords: lectin, antiadhesive, thiogalactoside, rna binding protein, sugar binding protein
• Biological source: Pseudomonas aeruginosa PAO1
• Total number of polymer chains: 4
• Total formula weight: 53289.04

Authors

Varrot, A. (deposition date: 2022-03-10, release date: 2023-01-18, Last modification date: 2024-01-31)

• Primary citation: Bruneau, A.,Gillon, E.,Furiga, A.,Brachet, E.,Alami, M.,Roques, C.,Varrot, A.,Imberty, A.,Messaoudi, S.; Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties.; Eur.J.Med.Chem., 247:115025-115025, 2022; PubMed: 36549118; DOI: 10.1016/j.ejmech.2022.115025

Experimental method

X-RAY DIFFRACTION (1.75 Å)