5M1Z

STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR

Summary for 5M1Z

Entry DOI	10.2210/pdb5m1z/pdb
Descriptor	Exo-1,5-alpha-L-arabinofuranobiosidase, alpha-L-arabinofuranose-(1-5)-(Z)-L-Arabinonhydroximo-1,4-lactone, SULFATE ION, ... (7 entities in total)
Functional Keywords	arabinofuramisodase, inhibitor, complex, hydrolase
Biological source	Gibberella zeae (Wheat head blight fungus)
Total number of polymer chains	1
Total formula weight	42270.83
Authors	Varrot, A. (deposition date: 2016-10-11, release date: 2016-12-28, Last modification date: 2024-01-17)
Primary citation	Coyle, T.,Debowski, A.W.,Varrot, A.,Stubbs, K.A. Exploiting sp(2) -Hybridisation in the Development of Potent 1,5-alpha-l-Arabinanase Inhibitors. Chembiochem, 18:974-978, 2017 Cited by PubMed Abstract: The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity are described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis of the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases. PubMed: 28266777 DOI: 10.1002/cbic.201700073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation