6XKE
 
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6XL7
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6XMB
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3NP1
 | | CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE | | Descriptor: | CYANIDE ION, NITROPHORIN 1, PHOSPHATE ION, ... | | Authors: | Weichsel, A, Andersen, J.F, Champagne, D.E, Walker, F.A, Montfort, W.R. | | Deposit date: | 1998-01-22 | | Release date: | 1998-05-27 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of a nitric oxide transport protein from a blood-sucking insect.
Nat.Struct.Biol., 5, 1998
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7MJ5
 | | complex of human thrombin with XC-43 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Putative secreted salivary protein, SODIUM ION, ... | | Authors: | Lu, S, Tirloni, L, Andersen, J.F. | | Deposit date: | 2021-04-19 | | Release date: | 2021-12-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis.
J.Biol.Chem., 297, 2021
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7KC8
 | | Salivary protein from Culex quinquefasciatus that belongs to the Cysteins and Tryptophan-Rich (CWRC) family | | Descriptor: | 16.4 kDa salivary peptide, ACETIC ACID | | Authors: | Garboczi, D.N, Gittis, A.G, Kern, O, Martin-Martin, I. | | Deposit date: | 2020-10-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structures of two salivary proteins from the West Nile vector Culex quinquefasciatus reveal a beta-trefoil fold with putative sugar binding properties
Curr Res Struct Biol, 3, 2021
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7KCG
 | | Salivary protein from Culex quiquefasciatus that belongs to the Cysteine and Tryptophan-Rich (CWRC) family | | Descriptor: | 16 kDa salivary peptide, FORMIC ACID | | Authors: | Garboczi, N.D, Gittis, A.G, Kern, O, Martin-Martin, I, Calvo, E. | | Deposit date: | 2020-10-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | The structures of two salivary proteins from the West Nile vector Culex quinquefasciatus reveal a beta-trefoil fold with putative sugar binding properties
Curr Res Struct Biol, 3, 2021
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5K6D
 | | Structure of FS50 an antagonist of NaV1.5 | | Descriptor: | Putative secreted salivary protein | | Authors: | Andersen, J.F, Xu, X. | | Deposit date: | 2016-05-24 | | Release date: | 2016-11-23 | | Method: | X-RAY DIFFRACTION (1.139 Å) | | Cite: | Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.
Sci Rep, 6, 2016
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4JD9
 | | Contact pathway inhibitor from a sand fly | | Descriptor: | 14.5 kDa salivary protein, SULFATE ION | | Authors: | Andersen, J.F, Xu, X, Alvarenga, P. | | Deposit date: | 2013-02-24 | | Release date: | 2013-10-16 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Arterioscler Thromb Vasc Biol, 33, 2013
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4TPV
 | | Crystal Structure of Hookworm Platelet Inhibitor | | Descriptor: | GLYCEROL, Platelet inhibitor | | Authors: | Andersen, J.F, Ma, D, Francischetti, I. | | Deposit date: | 2014-06-09 | | Release date: | 2015-04-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum.
Acta Crystallogr.,Sect.F, 71, 2015
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5H9N
 | | Crystal structure of LTBP1 Y114A mutant in complex with leukotriene C4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-28 | | Release date: | 2016-05-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5H9L
 | | Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4 | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, GLUTATHIONE, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-28 | | Release date: | 2016-05-11 | | Last modified: | 2016-07-27 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5HA0
 | | Crystal structure of the LTBP1 leukotriene d4 complex | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-29 | | Release date: | 2016-05-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.441 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5HAE
 | | Crystal structure of LTBP1 LTC4 complex collected on an in-house source | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, GLUTATHIONE, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-30 | | Release date: | 2016-05-11 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5H9K
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3U3U
 | | Crystal structure of the tablysin-15-leukotriene E4 complex | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, CITRIC ACID, PRASEODYMIUM ION, ... | | Authors: | Andersen, J.F. | | Deposit date: | 2011-10-06 | | Release date: | 2012-02-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain.
J.Biol.Chem., 287, 2012
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3U3N
 | | Crystal structure of tablysin-15 | | Descriptor: | CITRIC ACID, PALMITIC ACID, PRASEODYMIUM ION, ... | | Authors: | Andersen, J.F. | | Deposit date: | 2011-10-06 | | Release date: | 2012-02-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.651 Å) | | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain.
J.Biol.Chem., 287, 2012
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3NDA
 | | Crystal structure of serpin from tick Ixodes ricinus | | Descriptor: | PENTAETHYLENE GLYCOL, Serpin-2 | | Authors: | Rezacova, P, Kovarova, Z, Chmelar, J, Mares, M. | | Deposit date: | 2010-06-07 | | Release date: | 2010-10-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
Blood, 117, 2011
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1NP1
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2NP1
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4NP1
 | | NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE | | Descriptor: | NITRIC OXIDE, NITROPHORIN 1, PHOSPHATE ION, ... | | Authors: | Weichsel, A, Andersen, J.F, Walker, F.A, Montfort, W.R. | | Deposit date: | 1998-06-26 | | Release date: | 1998-11-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Nitric Oxide Binding to the Ferri-and Ferroheme States of Nitrophorin 1, a Reversible No-Binding Heme Protein from the Saliva of the Blood-Sucking Insect, Rhodnius Prolixus
To be Published
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5V13
 | | Mosquito juvenile hormone-binding protein | | Descriptor: | AAEL008620-PA odorant-binding protein, methyl (2E,6E)-9-[(2R)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate | | Authors: | Andersen, J.F, Kim, I.H. | | Deposit date: | 2017-03-01 | | Release date: | 2017-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone.
J. Biol. Chem., 292, 2017
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8UIN
 | | Structure of the C3bBb-albicin complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2023-10-10 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.
Commun Biol, 7, 2024
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8ENU
 | | Structure of the C3bB proconvertase in complex with lufaxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2022-09-30 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8EO2
 | | Lufaxin a bifunctional inhibitor of complement and coagulation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | Authors: | Andersen, J.F, Strayer, E.C. | | Deposit date: | 2022-10-01 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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