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3GNY
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BU of 3gny by Molmil
Crystal structure of human alpha-defensin 1 (HNP1)
Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.-Y.
Deposit date:2009-03-18
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
3GO0
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BU of 3go0 by Molmil
Crystal structure of D-enantiomer of human alpha-defensin 1 (D-HNP1)
Descriptor: CHLORIDE ION, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.-Y.
Deposit date:2009-03-18
Release date:2009-07-28
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
2NLC
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BU of 2nlc by Molmil
Human beta-defensin-1 (mutant Ser8Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLH
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BU of 2nlh by Molmil
Human beta-defensin-1 (Mutant GLN24ALA)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLP
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BU of 2nlp by Molmil
Human beta-defensin-1 (Mutant Gln24Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLS
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BU of 2nls by Molmil
Human beta-defensin-1 (Mutant Gln24Ala)
Descriptor: Beta-defensin 1
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLD
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BU of 2nld by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLB
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BU of 2nlb by Molmil
Human beta-defensin-1 (Mutant Asn4Ala)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLG
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BU of 2nlg by Molmil
Human beta-defensin-1 (Mutant Lys22Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLQ
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BU of 2nlq by Molmil
Human beta-defensin-1 (Mutant Lys31Ala)
Descriptor: Beta-defensin 1, GLYCEROL, GLYCINE, ...
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLE
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BU of 2nle by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLF
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BU of 2nlf by Molmil
Human beta-defensin-1 (Mutant Leu13Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
8CZZ
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BU of 8czz by Molmil
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Y, Pozharski, E, Tolbert, W, Pazgier, M.
Deposit date:2022-05-25
Release date:2023-05-31
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
7RPV
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BU of 7rpv by Molmil
Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:Chen, Y, Tolbert, D.W, Pazgier, M.
Deposit date:2021-08-04
Release date:2021-12-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Biorxiv, 2021
8DOK
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BU of 8dok by Molmil
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Y, Zhou, F, Huang, R, Tolbert, W, Pazgier, M.
Deposit date:2022-07-13
Release date:2023-07-19
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
5WB9
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BU of 5wb9 by Molmil
Crystal structure of CD4 binding site antibody N60P23 in complex with HIV-1 clade A/E strain 93TH057 gp120 core
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ...
Authors:Gohain, N, Tolbert, W, Pazgier, M.
Deposit date:2017-06-28
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.
Cell, 173, 2018
6MFP
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BU of 6mfp by Molmil
Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Tolbert, W.D, Young, B, Pazgier, M.
Deposit date:2018-09-11
Release date:2019-09-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.
J.Virol., 94, 2020
5KJR
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BU of 5kjr by Molmil
Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2016-06-20
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
J.Virol., 90, 2016
5FCU
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BU of 5fcu by Molmil
CRYSTAL STRUCTURE OF THE INNER DOMAIN OF CLADE A/E HIV-1 GP120 IN COMPLEX WITH THE ADCC-POTENT RHESUS MACAQUE ANTIBODY JR4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, JR4 FAB HEAVY CHAIN, ...
Authors:Gohain, N, Tolbert, W.D, Pazgier, M.
Deposit date:2015-12-15
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Structure, 24, 2016
8TTW
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BU of 8ttw by Molmil
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tolbert, W.D, Pozharski, E, Pazgier, M.
Deposit date:2023-08-15
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
1T3M
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BU of 1t3m by Molmil
Structure of the isoaspartyl peptidase with L-asparaginase activity from E. coli
Descriptor: NITRATE ION, Putative L-asparaginase, SODIUM ION
Authors:Prahl, A, Pazgier, M, Hejazi, M, Lockau, W, Lubkowski, J.
Deposit date:2004-04-27
Release date:2004-07-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli.
Acta Crystallogr.,Sect.D, 60, 2004
8SM2
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BU of 8sm2 by Molmil
Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig-like domain-containing protein, Immunoglobulin subtype domain-containing protein, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2023-04-25
Release date:2024-05-08
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
To Be Published
8CTM
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BU of 8ctm by Molmil
Crystal structure of the nucleoside hydrolase from Leishmania donovani.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Chen, Y, Tolbert, W.D, Pazgier, M.
Deposit date:2022-05-16
Release date:2023-06-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of the nucleoside hydrolase from Leishmania donovani.
To Be Published
8DCQ
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BU of 8dcq by Molmil
CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH YIR-821
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HT Clade A/E CRF01 gp120 core, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2022-06-17
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates.
J.Virol., 97, 2023
4DU0
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BU of 4du0 by Molmil
Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)
Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
Authors:Wu, X, Lu, W, Pazgier, M.
Deposit date:2012-02-21
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012

226707

数据于2024-10-30公开中

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