4X58
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![BU of 4x58 by Molmil](/molmil-images/mine/4x58) | Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-04 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X59
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![BU of 4x59 by Molmil](/molmil-images/mine/4x59) | Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-04 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5A
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![BU of 4x5a by Molmil](/molmil-images/mine/4x5a) | |
4X5E
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![BU of 4x5e by Molmil](/molmil-images/mine/4x5e) | Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-11-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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3QQ1
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![BU of 3qq1 by Molmil](/molmil-images/mine/3qq1) | |
4X5C
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![BU of 4x5c by Molmil](/molmil-images/mine/4x5c) | Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ... | Authors: | Cookson, T.V.M, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5D
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![BU of 4x5d by Molmil](/molmil-images/mine/4x5d) | Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis with anthranilate bound | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5B
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![BU of 4x5b by Molmil](/molmil-images/mine/4x5b) | |
3RZI
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![BU of 3rzi by Molmil](/molmil-images/mine/3rzi) | The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan | Descriptor: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Jiao, W, Jameson, G.B, Hutton, R.D, Parker, E.J. | Deposit date: | 2011-05-11 | Release date: | 2012-01-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery. J.Mol.Biol., 415, 2012
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6PBJ
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![BU of 6pbj by Molmil](/molmil-images/mine/6pbj) | The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | Authors: | Jiao, W, Fan, Y, Blackmore, N.J, Parker, E.J. | Deposit date: | 2019-06-13 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis . J.Biol.Chem., 295, 2020
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4YB6
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![BU of 4yb6 by Molmil](/molmil-images/mine/4yb6) | Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the inhibitors AMP and histidine | Descriptor: | ADENOSINE MONOPHOSPHATE, ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Mittelstaedt, G, Moggre, G.-J, Parker, E.J. | Deposit date: | 2015-02-18 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail. Protein Sci., 25, 2016
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3RMJ
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![BU of 3rmj by Molmil](/molmil-images/mine/3rmj) | Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis | Descriptor: | 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J. | Deposit date: | 2011-04-20 | Release date: | 2012-03-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding Biochemistry, 51, 2012
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6BMC
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![BU of 6bmc by Molmil](/molmil-images/mine/6bmc) | The structure of a dimeric type II DAH7PS associated with pyocyanin biosynthesis in Pseudomonas aeruginosa | Descriptor: | CHLORIDE ION, COBALT (II) ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Sterritt, O.W, Jameson, G.B, Parker, E.J. | Deposit date: | 2017-11-14 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and functional characterisation of the entry point to pyocyanin biosynthesis inPseudomonas aeruginosadefines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass. Biosci. Rep., 38, 2018
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4YB5
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![BU of 4yb5 by Molmil](/molmil-images/mine/4yb5) | Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with the allosteric inhibitor histidine | Descriptor: | ATP phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, HISTIDINE, ... | Authors: | Mittelstaedt, G, Moggre, G.-J, Parker, E.J. | Deposit date: | 2015-02-18 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail. Protein Sci., 25, 2016
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3QQ0
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![BU of 3qq0 by Molmil](/molmil-images/mine/3qq0) | Crystal structure of a deletion mutant (N59) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ... | Authors: | Allison, T.M, Jameson, G.B, Parker, E.J. | Deposit date: | 2011-02-14 | Release date: | 2011-04-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase Biochemistry, 50, 2011
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4C1K
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![BU of 4c1k by Molmil](/molmil-images/mine/4c1k) | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase | Descriptor: | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATE ALDOLASE, CADMIUM ION, CARBONATE ION, ... | Authors: | Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J. | Deposit date: | 2013-08-13 | Release date: | 2013-11-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Destabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity J.Mol.Biol., 426, 2014
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4YB7
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![BU of 4yb7 by Molmil](/molmil-images/mine/4yb7) | Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni in complex with ATP | Descriptor: | ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP phosphoribosyltransferase, ... | Authors: | Mittelstaedt, G, Moggre, G.-J, Parker, E.J. | Deposit date: | 2015-02-18 | Release date: | 2016-03-09 | Last modified: | 2018-09-05 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail. Protein Sci., 25, 2016
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3STF
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![BU of 3stf by Molmil](/molmil-images/mine/3stf) | Crystal structure of a mutant (S211A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ... | Authors: | Allison, T.M, Jameson, G.B, Gloyne, B.J, Parker, E.J. | Deposit date: | 2011-07-09 | Release date: | 2011-11-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase Biochemistry, 50, 2011
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3STC
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3STG
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![BU of 3stg by Molmil](/molmil-images/mine/3stg) | Crystal structure of A58P, DEL(N59), and loop 7 truncated mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION | Authors: | Allison, T.M, Jameson, G.B, Parker, E.J. | Deposit date: | 2011-07-09 | Release date: | 2011-11-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase Biochemistry, 50, 2011
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3STE
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![BU of 3ste by Molmil](/molmil-images/mine/3ste) | Crystal structure of a mutant (Q202A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, SODIUM ION | Authors: | Allison, T.M, Jameson, G.B, Gloyne, B.J, Parker, E.J. | Deposit date: | 2011-07-09 | Release date: | 2011-11-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase Biochemistry, 50, 2011
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4C1L
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![BU of 4c1l by Molmil](/molmil-images/mine/4c1l) | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase I181D interface mutant | Descriptor: | 2-dehydro-3-deoxyphosphoheptonate aldolase, CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J. | Deposit date: | 2013-08-13 | Release date: | 2013-11-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity. J. Mol. Biol., 426, 2014
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3QPZ
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![BU of 3qpz by Molmil](/molmil-images/mine/3qpz) | Crystal structure of the N59A mutant of the 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ... | Authors: | Allison, T.M, Jameson, G.B, Parker, E.J, Cochrane, F.C. | Deposit date: | 2011-02-14 | Release date: | 2011-04-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase Biochemistry, 50, 2011
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2QKF
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![BU of 2qkf by Molmil](/molmil-images/mine/2qkf) | Crystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | Descriptor: | 3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase, CHLORIDE ION, GLYCEROL, ... | Authors: | Cochrane, F.C, Patchett, M.L, Jameson, G.B, Parker, E.J. | Deposit date: | 2007-07-11 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Re-Establishing a Metal-Binding Scaffold with Full Activity in the Metal-Independent Kdo8P Synthase from Neisseria Meningitidis To be Published
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6AL9
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![BU of 6al9 by Molmil](/molmil-images/mine/6al9) | Crystal structure of chorismate mutase from Helicobacter pylori in complex with prephenate | Descriptor: | Chorismate mutase, P-HYDROXYBENZOIC ACID, PREPHENIC ACID, ... | Authors: | Fan, Y, Jameson, G.B, Panjikar, S, Parker, E.J. | Deposit date: | 2017-08-07 | Release date: | 2018-11-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of chorismate mutase from Helicobacter pylori in complex with prephenate To Be Published
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