4X5D

Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis with anthranilate bound

Summary for 4X5D

Entry DOI	10.2210/pdb4x5d/pdb
Related	4X58 4X59 4X5A 4X5B 4X5C 4X5E
Descriptor	Anthranilate phosphoribosyltransferase, 2-AMINOBENZOIC ACID, IMIDAZOLE, ... (5 entities in total)
Functional Keywords	anthranilate phosphoribosyltransferase, anthranilic acids, mycobacterium tuberculosis, magnesium, tryptophan, mutation, transferase, magnesium binding, phosphoribosyl pyrophosphate
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	78053.08
Authors	Cookson, T.V.M.,Parker, E.J.,Lott, J.S. (deposition date: 2014-12-05, release date: 2015-09-23, Last modification date: 2023-11-15)
Primary citation	Cookson, T.V.,Evans, G.L.,Castell, A.,Baker, E.N.,Lott, J.S.,Parker, E.J. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54:6082-6092, 2015 Cited by PubMed: 26356348 DOI: 10.1021/acs.biochem.5b00612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation