4X5D
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis with anthranilate bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue BE2 A 401 |
| Chain | Residue |
| A | ASN138 |
| A | ALA179 |
| A | PRO180 |
| A | HIS183 |
| A | TYR186 |
| A | ALA190 |
| A | ARG194 |
| A | HOH591 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 402 |
| Chain | Residue |
| A | GLY306 |
| A | ILE351 |
| A | ASP352 |
| A | GLU357 |
| A | LEU305 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | THR273 |
| A | PHE274 |
| A | ASP275 |
| A | GLY278 |
| A | TRP336 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue BE2 B 401 |
| Chain | Residue |
| B | ASN138 |
| B | HIS183 |
| B | TYR186 |
| B | ARG187 |
| B | ALA190 |
| B | ARG194 |
| B | HOH553 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | PHE274 |
| B | ASP275 |
| B | PHE279 |
| B | TRP336 |
| B | HOH509 |
| B | HOH520 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211 |
| Chain | Residue | Details |
| A | GLY107 | |
| B | GLY107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASN138 | |
| A | ALA193 | |
| A | ASP251 | |
| A | GLU252 | |
| B | GLY110 | |
| B | ASN117 | |
| B | SER119 | |
| B | LYS135 | |
| B | ASN138 | |
| B | ALA193 | |
| B | ASP251 | |
| B | GLU252 | |
| A | GLY110 | |
| A | ASN117 | |
| A | SER119 | |
| A | LYS135 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5 |
| Chain | Residue | Details |
| A | THR115 | |
| A | GLY147 | |
| B | THR115 | |
| B | GLY147 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
