1X8K
 
 | | Crystal structure of retinol dehydratase in complex with anhydroretinol and inactive cofactor PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, ANHYDRORETINOL, CALCIUM ION, ... | | Authors: | Pakhomova, S, Buck, J, Newcomer, M.E. | | Deposit date: | 2004-08-18 | | Release date: | 2005-02-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition.
Protein Sci., 14, 2005
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6NS6
 | | Crystal structure of fungal lipoxygenase from Fusarium graminearum. P21 crystal form. | | Descriptor: | FE (II) ION, lipoxygenase | | Authors: | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2019-01-24 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
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6NS5
 | | Crystal structure of fungal lipoxygenase from Fusarium graminearum. Second C2 crystal form. | | Descriptor: | FE (II) ION, lipoxygenase | | Authors: | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2019-01-24 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
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6NS2
 | | Crystal structure of fungal lipoxygenase from Fusarium graminearum. P212121 crystal form. | | Descriptor: | FE (II) ION, lipoxygenase | | Authors: | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2019-01-24 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
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6NS3
 | | Crystal structure of fungal lipoxygenase from Fusarium graminearum. I222 crystal form. | | Descriptor: | FE (II) ION, lipoxygenase | | Authors: | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2019-01-24 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
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6NS4
 | | Crystal structure of fungal lipoxygenase from Fusarium graminearum. C2 crystal form. | | Descriptor: | ACETATE ION, FE (II) ION, GLYCEROL, ... | | Authors: | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2019-01-24 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere.
Protein Sci., 28, 2019
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2FBK
 | | The Crystal Structure of HucR from Deinococcus radiodurans | | Descriptor: | CHLORIDE ION, transcriptional regulator, MarR family | | Authors: | Bordelon, T, Wilkinson, S.P, Grove, A, Newcomer, M.E. | | Deposit date: | 2005-12-09 | | Release date: | 2006-07-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Crystal Structure of the Transcriptional Regulator HucR from Deinococcus radiodurans Reveals a Repressor Preconfigured for DNA Binding.
J.Mol.Biol., 360, 2006
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2FNQ
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3THS
 | | Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate pentaglutamate | | Descriptor: | 5-methyltetrahydrofolate pentaglutamate, BETA-MERCAPTOETHANOL, Glycine N-methyltransferase, ... | | Authors: | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Newcomer, M.E, Wagner, C. | | Deposit date: | 2011-08-19 | | Release date: | 2011-11-16 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.
Biochim.Biophys.Acta, 1824, 2011
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3THR
 | | Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate monoglutamate | | Descriptor: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Glycine N-methyltransferase, TRIS(HYDROXYETHYL)AMINOMETHANE | | Authors: | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Newcomer, M.E, Wagner, C. | | Deposit date: | 2011-08-19 | | Release date: | 2011-11-16 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.
Biochim.Biophys.Acta, 1824, 2011
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1FMJ
 | | CRYSTAL STRUCTURE OF MERCURY DERIVATIVE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, MERCURY (II) ION, ... | | Authors: | Pakhomova, S, Kobayashi, M, Buck, J, Newcomer, M.E. | | Deposit date: | 2000-08-17 | | Release date: | 2001-05-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A helical lid converts a sulfotransferase to a dehydratase.
Nat.Struct.Biol., 8, 2001
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1FML
 | | CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, RETINOL, ... | | Authors: | Pakhomova, S, Kobayashi, M, Buck, J, Newcomer, M.E. | | Deposit date: | 2000-08-17 | | Release date: | 2001-05-02 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | A helical lid converts a sulfotransferase to a dehydratase.
Nat.Struct.Biol., 8, 2001
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3VF1
 | | Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca-regulation | | Descriptor: | 11R-lipoxygenase, FE (II) ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Eek, P, Jarving, R, Jarving, I, Gilbert, N.C, Newcomer, M.E, Samel, N. | | Deposit date: | 2012-01-09 | | Release date: | 2012-05-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.473 Å) | | Cite: | Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation.
J.Biol.Chem., 287, 2012
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3V99
 | | S663D Stable-5-LOX in complex with Arachidonic Acid | | Descriptor: | ARACHIDONIC ACID, Arachidonate 5-lipoxygenase, FE (II) ION | | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2011-12-23 | | Release date: | 2012-05-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.252 Å) | | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
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3V92
 | | S663A Stable-5-LOX | | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2011-12-23 | | Release date: | 2012-05-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
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3V98
 | | S663D Stable-5-LOX | | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | | Deposit date: | 2011-12-23 | | Release date: | 2012-05-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Faseb J., 26, 2012
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3FG1
 | | Crystal structure of Delta413-417:GS LOX | | Descriptor: | ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ... | | Authors: | Neau, D.B, Newcomer, M.E. | | Deposit date: | 2008-12-04 | | Release date: | 2009-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
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3FG4
 | | Crystal structure of Delta413-417:GS I805A LOX | | Descriptor: | ACETIC ACID, ARACHIDONIC ACID, Allene oxide synthase-lipoxygenase protein, ... | | Authors: | Neau, D.B, Newcomer, M.E. | | Deposit date: | 2008-12-04 | | Release date: | 2009-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
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3FG3
 | | Crystal structure of Delta413-417:GS I805W LOX | | Descriptor: | ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ... | | Authors: | Neau, D.B, Newcomer, M.E. | | Deposit date: | 2008-12-04 | | Release date: | 2009-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009
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1RBP
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3QUR
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin monophosphate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | | Authors: | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | Deposit date: | 2011-02-24 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QUN
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, FomA protein, GLYCEROL, ... | | Authors: | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | Deposit date: | 2011-02-24 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QUO
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ATP and fosfomycin | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, FOSFOMYCIN, FomA protein | | Authors: | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | Deposit date: | 2011-02-24 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QVH
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FomA protein | | Authors: | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | Deposit date: | 2011-02-25 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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3QVF
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin vanadate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | | Authors: | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | | Deposit date: | 2011-02-25 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.
Biochemistry, 50, 2011
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