3THS
Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate pentaglutamate
Summary for 3THS
Entry DOI | 10.2210/pdb3ths/pdb |
Related | 2IDK 3THR |
Related PRD ID | PRD_000833 |
Descriptor | Glycine N-methyltransferase, 5-methyltetrahydrofolate pentaglutamate, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | glycine n-methyltransferase, gnmt, folate, folate binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cytoplasm: P13255 |
Total number of polymer chains | 6 |
Total formula weight | 132140.65 |
Authors | Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C. (deposition date: 2011-08-19, release date: 2011-11-16, Last modification date: 2023-09-13) |
Primary citation | Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C. Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Biochim.Biophys.Acta, 1824:286-291, 2011 Cited by PubMed: 22037183DOI: 10.1016/j.bbapap.2011.10.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report