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6PLW
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BU of 6plw by Molmil
CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, super-open state
Descriptor: GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Yu, J, Zhu, H, Gouaux, E.
Deposit date:2019-07-01
Release date:2021-02-10
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism of gating and partial agonist action in the glycine receptor.
Cell, 184, 2021
7LWD
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BU of 7lwd by Molmil
Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ...
Authors:Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J.
Deposit date:2021-03-01
Release date:2021-08-11
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Nat Commun, 12, 2021
7MGW
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BU of 7mgw by Molmil
5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2021-04-13
Release date:2021-12-15
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Illumination of serotonin transporter mechanism and role of the allosteric site.
Sci Adv, 7, 2021
7LDE
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BU of 7lde by Molmil
native AMPA receptor
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Yu, J, Rao, P, Gouaux, E.
Deposit date:2021-01-13
Release date:2021-05-12
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Nature, 594, 2021
7LEP
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BU of 7lep by Molmil
The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25 Angstrom resolution
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, DECANE, ...
Authors:Yu, J, Rao, P, Gouaux, E.
Deposit date:2021-01-14
Release date:2021-05-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Nature, 594, 2021
7MLV
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BU of 7mlv by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
7MLU
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BU of 7mlu by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
7MLY
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BU of 7mly by Molmil
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Descriptor: 3D1 Fab Heavy Chain, 3D1 Fab Light Chain, DECANE, ...
Authors:Zhu, H, Gouaux, E.
Deposit date:2021-04-29
Release date:2021-09-29
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Architecture and assembly mechanism of native glycine receptors.
Nature, 599, 2021
4MM8
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BU of 4mm8 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with (R)-fluoxetine
Descriptor: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, SODIUM ION, Transporter
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MMF
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BU of 4mmf by Molmil
Crystal structure of LeuBAT (delta5 mutant) in complex with mazindol
Descriptor: (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ...
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MM4
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BU of 4mm4 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with paroxetine
Descriptor: CHLORIDE ION, Paroxetine, SODIUM ION, ...
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.886 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MM9
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BU of 4mm9 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with fluvoxamine
Descriptor: Fluvoxamine, SODIUM ION, Transporter
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MMA
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BU of 4mma by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with clomipramine
Descriptor: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, SODIUM ION, Transporter
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
6MMR
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BU of 6mmr by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (5.13 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMB
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BU of 6mmb by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-09-30
Release date:2018-11-28
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (12.7 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMS
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BU of 6mms by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (5.38 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
4MM5
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BU of 4mm5 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with sertraline
Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MMB
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BU of 4mmb by Molmil
Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline
Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ...
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
6MMV
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BU of 6mmv by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.71 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
4MME
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BU of 4mme by Molmil
Crystal structure of LeuBAT (delta6 mutant) in complex with mazindol
Descriptor: (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ...
Authors:Wang, H, Gouaux, E.
Deposit date:2013-09-08
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
6MMG
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BU of 6mmg by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-09-30
Release date:2018-11-28
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (6.23 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMX
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BU of 6mmx by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (6.99 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMN
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BU of 6mmn by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 8.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (7.51 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMJ
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BU of 6mmj by Molmil
Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-09-30
Release date:2018-11-28
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (16.5 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
6MMW
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BU of 6mmw by Molmil
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E.
Deposit date:2018-10-01
Release date:2018-11-28
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018

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数据于2025-07-09公开中

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