7LEP

The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25 Angstrom resolution

Summary for 7LEP

• Entry DOI: 10.2210/pdb7lep/pdb
• EMDB information: 23292
• Descriptor: Mix of AMPAR subunits (GluA1, GluA3, and GluA4), 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, N-OCTANE, ... (12 entities in total)
• Functional Keywords: native hippocampal ion channel, membrane protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 8
• Total formula weight: 291860.09

Authors

Yu, J.,Rao, P.,Gouaux, E. (deposition date: 2021-01-14, release date: 2021-05-12, Last modification date: 2021-06-30)

• Primary citation: Yu, J.,Rao, P.,Clark, S.,Mitra, J.,Ha, T.,Gouaux, E.; Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.; Nature, 594:448-453, 2021; PubMed: 33981040; DOI: 10.1038/s41586-021-03540-0

Experimental method

ELECTRON MICROSCOPY (3.25 Å)