7LEP
The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mix of AMPAR subunits (GluA1, GluA3, and GluA4) | polymer | 414 | 43650.7 | 1 | Mus musculus (Mouse) | ||
| 2 | B, D (B, D) | Glutamate receptor 2 | polymer | 424 | 47252.3 | 2 | UniProt (C9K0Z0) Pfam (PF10613) Pfam (PF00060) UniProt (by SIFTS) (P23819) | Mus musculus (Mouse) | |
| 3 | C (C) | Mix of AMPAR subunits (GluA1, GluA3, and GluAX) | polymer | 413 | 43702.6 | 1 | Mus musculus (Mouse) | ||
| 4 | E, F (E, F) | Protein cornichon homolog 2 | polymer | 159 | 18755.2 | 2 | UniProt (O35089) Pfam (PF03311) | Mus musculus (Mouse) | CNIH-2,Cornichon family AMPA receptor auxiliary protein 2,Cornichon-like protein |
| 5 | G, H (G, H) | Voltage-dependent calcium channel gamma-8 subunit | polymer | 215 | 23242.7 | 2 | UniProt (Q8VHW2) Pfam (PF00822) | Mus musculus (Mouse) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 6 | HA, I, R, Y (D, A, B, C) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 7 | AA, BA, CA, DA, EA... (C, D, A, E, F...) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 30 | Chemie (POV) | |||
| 8 | T (B) | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
| 9 | Z (C) | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) | |||
| 10 | QA, UA (G, H) | 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol | non-polymer | 328.7 | 2 | Chemie (XVD) | |||
| 11 | RA, VA (G, H) | N-OCTANE | non-polymer | 114.2 | 2 | Chemie (OCT) | |||
| 12 | SA, WA (G, H) | DODECANE | non-polymer | 170.3 | 2 | Chemie (D12) |
Sequence modifications
B, D: 396 - 819 (UniProt: C9K0Z0)
E, F: 2 - 160 (UniProt: O35089)
| PDB | External Database | Details |
|---|---|---|
| Glu 756 | Gln 777 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 100 | Tyr 100 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 265853.7 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 26006.4 | |
| All* | Total formula weight | 291860.1 |
