7LEP

The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity
E	0005102	molecular_function	signaling receptor binding
E	0005515	molecular_function	protein binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0014069	cellular_component	postsynaptic density
E	0016192	biological_process	vesicle-mediated transport
E	0016247	molecular_function	channel regulator activity
E	0030425	cellular_component	dendrite
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0035249	biological_process	synaptic transmission, glutamatergic
E	0042391	biological_process	regulation of membrane potential
E	0043197	cellular_component	dendritic spine
E	0043198	cellular_component	dendritic shaft
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0051668	biological_process	localization within membrane
E	0098839	cellular_component	postsynaptic density membrane
E	0098978	cellular_component	glutamatergic synapse
E	1902684	biological_process	negative regulation of receptor localization to synapse
E	1903743	biological_process	negative regulation of anterograde synaptic vesicle transport
E	2000310	biological_process	regulation of NMDA receptor activity
E	2000311	biological_process	regulation of AMPA receptor activity
F	0005102	molecular_function	signaling receptor binding
F	0005515	molecular_function	protein binding
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0014069	cellular_component	postsynaptic density
F	0016192	biological_process	vesicle-mediated transport
F	0016247	molecular_function	channel regulator activity
F	0030425	cellular_component	dendrite
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0035249	biological_process	synaptic transmission, glutamatergic
F	0042391	biological_process	regulation of membrane potential
F	0043197	cellular_component	dendritic spine
F	0043198	cellular_component	dendritic shaft
F	0045202	cellular_component	synapse
F	0045211	cellular_component	postsynaptic membrane
F	0051668	biological_process	localization within membrane
F	0098839	cellular_component	postsynaptic density membrane
F	0098978	cellular_component	glutamatergic synapse
F	1902684	biological_process	negative regulation of receptor localization to synapse
F	1903743	biological_process	negative regulation of anterograde synaptic vesicle transport
F	2000310	biological_process	regulation of NMDA receptor activity
F	2000311	biological_process	regulation of AMPA receptor activity
G	0006816	biological_process	calcium ion transport
G	0016020	cellular_component	membrane
H	0006816	biological_process	calcium ion transport
H	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01340
Number of Residues	15
Details	CORNICHON Cornichon family signature. IafdELrtDFkNPID

Chain	Residue	Details
E	ILE29-ASP43

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	30
Details	Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	348
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"16129400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	280
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---