2X8I
| Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration | Descriptor: | 7-(3-hydroxyphenyl)-5-methyl[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Otterbein, L, Vallentine, A, White, A. | Deposit date: | 2010-03-09 | Release date: | 2010-08-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration. Bioorg.Med.Chem., 20, 2010
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7FJ1
| Cryo-EM structure of pseudorabies virus C-capsid | Descriptor: | Capsid vertex component 1, DNA packaging tegument protein UL25, Major capsid protein, ... | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | Deposit date: | 2021-08-02 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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6L7D
| Mycobacterium tuberculosis enolase mutant - S42A | Descriptor: | 1,2-ETHANEDIOL, 2-PHOSPHOGLYCERIC ACID, ACETATE ION, ... | Authors: | Ahmad, M, Jha, B, Tiwari, S, Dwivedy, A, Biswal, B.K. | Deposit date: | 2019-11-01 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis. Iucrj, 10, 2023
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7FJ3
| Cryo-EM structure of PRV A-capid | Descriptor: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | Deposit date: | 2021-08-02 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (4.53 Å) | Cite: | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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7W1Q
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7X39
| Structure of CIZ1 bound ERH | Descriptor: | Enhancer of rudimentary homolog,Cip1-interacting zinc finger protein | Authors: | Wang, X, Xu, C. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Molecular basis for the recognition of CIZ1 by ERH. Febs J., 290, 2023
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3RAE
| Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | Descriptor: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 5'-D(*CP*AP*TP*GP*AP*AP*T)-3', 5'-D(*CP*GP*TP*GP*CP*AP*T)-3', ... | Authors: | Laponogov, I, Pan, X.-S, Veselkov, D.A, McAuley, K.E, Fisher, L.M, Sanderson, M.R. | Deposit date: | 2011-03-28 | Release date: | 2012-04-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex. Acta Crystallogr.,Sect.D, 72, 2016
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7XB4
| Crystal structure of SARS-Cov-2 main protease D48N mutant in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, Replicase polyprotein 1a | Authors: | Hu, X.H, Li, J, Zhang, J. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-10-02 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural Basis for the Inhibition of SARS-CoV-2 M pro D48N Mutant by Shikonin and PF-07321332. Viruses, 16, 2023
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7X3Y
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 9A3 (CVB1-E:9A3) | Descriptor: | 9A3 heavy chain, 9A3 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-03-01 | Release date: | 2023-06-07 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X35
| Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 8A10 (CVB1-A:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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2HHN
| Cathepsin S in complex with non covalent arylaminoethyl amide. | Descriptor: | Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, SULFATE ION | Authors: | Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K. | Deposit date: | 2006-06-28 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers Bioorg.Med.Chem.Lett., 16, 2006
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7XGW
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8K1C
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8K1F
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5MPS
| Structure of a spliceosome remodeled for exon ligation | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | Deposit date: | 2016-12-18 | Release date: | 2017-01-18 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Structure of a spliceosome remodelled for exon ligation. Nature, 542, 2017
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7X38
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 8A10 (CVB1-E:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X3F
| Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 9A3 (CVB1-A:9A3) | Descriptor: | 9A3 heavy chain, 9A3 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2G
| Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb nAb 2E6 (CVB1-E:2E6) | Descriptor: | 2E6 heavy chain, 2E6 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-25 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2O
| Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 2E6 (CVB1-M:2E6) | Descriptor: | 2E6 heavy chain, 2E6 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-25 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X42
| Cryo-EM structure of Coxsackievirus B1 pre-A-particle in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10 and 2E6) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP0, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-03-01 | Release date: | 2022-09-28 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2I
| Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 2E6 (CVB1-pre-A:2E6) | Descriptor: | 2E6 heavy chain, 2E6 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-25 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X49
| Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10 and 9A3) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-03-02 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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8K76
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7X2W
| Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 8A10 (CVB1-pre-A:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2T
| Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (CVB1-M:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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