3I94
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![BU of 3i94 by Molmil](/molmil-images/mine/3i94) | Crystal structure of PcyA-biliverdin XIII alpha complex | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-2-ylidene]methy l]-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, Phycocyanobilin:ferredoxin oxidoreductase, SULFATE ION | Authors: | Hagiwara, Y, Sugishima, M, Fukuyama, K. | Deposit date: | 2009-07-10 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA). to be published
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6KRO
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![BU of 6kro by Molmil](/molmil-images/mine/6kro) | Tankyrase-2 in complex with RK-582 | Descriptor: | 6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-fluoranyl-1-methyl-1'-(8-methyl-4-oxidanylidene-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-2-yl)spiro[indole-3,4'-piperidine]-2-one, GLYCEROL, PHOSPHATE ION, ... | Authors: | Niwa, H, Shirai, F, Sato, S, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | Deposit date: | 2019-08-22 | Release date: | 2020-04-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer. J.Med.Chem., 63, 2020
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6SS5
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![BU of 6ss5 by Molmil](/molmil-images/mine/6ss5) | Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | Authors: | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation. Proc.Natl.Acad.Sci.USA, 117, 2020
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6SS6
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![BU of 6ss6 by Molmil](/molmil-images/mine/6ss6) | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187 | Descriptor: | Arginase-2, mitochondrial, Fab C0020187 heavy chain (IgG1), ... | Authors: | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation. Proc.Natl.Acad.Sci.USA, 117, 2020
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6T6V
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![BU of 6t6v by Molmil](/molmil-images/mine/6t6v) | Glu-494-Ala inactive monomer of a quinol dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans | Descriptor: | CALCIUM ION, Nitric oxide reductase subunit B, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Gopalasingam, C.C, Johnson, R.M, Antonyuk, S.V, Muench, S.P, Hasnain, S.S. | Deposit date: | 2019-10-19 | Release date: | 2020-04-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The active form of quinol-dependent nitric oxide reductase fromNeisseria meningitidisis a dimer. Iucrj, 7, 2020
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3ORY
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![BU of 3ory by Molmil](/molmil-images/mine/3ory) | Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus | Descriptor: | PHOSPHATE ION, flap endonuclease 1 | Authors: | Mase, T, Kubota, K, Miyazono, K, Kawarabayashii, Y, Tanokura, M. | Deposit date: | 2010-09-08 | Release date: | 2011-02-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus Acta Crystallogr.,Sect.F, 67, 2011
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1CK6
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![BU of 1ck6 by Molmil](/molmil-images/mine/1ck6) | BINDING MODE OF SALICYLHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PROTEIN (PEROXIDASE), ... | Authors: | Fukuyama, K, Itakura, H. | Deposit date: | 1999-04-28 | Release date: | 1999-12-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Binding of salicylhydroxamic acid and several aromatic donor molecules to Arthromyces ramosus peroxidase, investigated by X-ray crystallography, optical difference spectroscopy, NMR relaxation, molecular dynamics, and kinetics. Biochemistry, 38, 1999
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1QI3
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![BU of 1qi3 by Molmil](/molmil-images/mine/1qi3) | MUTANT (D193N) MALTOTETRAOSE-FORMING EXO-AMYLASE IN COMPLEX WITH MALTOTETRAOSE | Descriptor: | CALCIUM ION, PROTEIN (EXO-MALTOTETRAOHYDROLASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Hasegawa, K, Kubota, M, Matsuura, Y. | Deposit date: | 1999-06-01 | Release date: | 1999-11-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Roles of catalytic residues in alpha-amylases as evidenced by the structures of the product-complexed mutants of a maltotetraose-forming amylase. Protein Eng., 12, 1999
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1QI5
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![BU of 1qi5 by Molmil](/molmil-images/mine/1qi5) | MUTANT (D294N) MALTOTETRAOSE-FORMING EXO-AMYLASE IN COMPLEX WITH MALTOTETRAOSE | Descriptor: | CALCIUM ION, PROTEIN (EXO-MALTOTETRAOHYDROLASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Hasegawa, K, Kubota, M, Matsuura, Y. | Deposit date: | 1999-06-03 | Release date: | 1999-11-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Roles of catalytic residues in alpha-amylases as evidenced by the structures of the product-complexed mutants of a maltotetraose-forming amylase. Protein Eng., 12, 1999
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1QI4
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![BU of 1qi4 by Molmil](/molmil-images/mine/1qi4) | MUTANT (E219G) MALTOTETRAOSE-FORMING EXO-AMYLASE IN COMPLEX WITH MALTOTETRAOSE | Descriptor: | CALCIUM ION, PROTEIN (EXO-MALTOTETRAOHYDROLASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Hasegawa, K, Kubota, M, Matsuura, Y. | Deposit date: | 1999-06-01 | Release date: | 1999-11-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Roles of catalytic residues in alpha-amylases as evidenced by the structures of the product-complexed mutants of a maltotetraose-forming amylase. Protein Eng., 12, 1999
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5ZUI
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![BU of 5zui by Molmil](/molmil-images/mine/5zui) | Crystal Structure of HSP104 from Chaetomium thermophilum | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Heat Shock Protein 104, SULFATE ION | Authors: | Hanazono, Y, Inoue, Y, Noguchi, K, Yohda, M, Shinohara, K, Takeda, K, Miki, K. | Deposit date: | 2018-05-07 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Split conformation of Chaetomium thermophilum Hsp104 disaggregase. Structure, 2021
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2D9S
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![BU of 2d9s by Molmil](/molmil-images/mine/2d9s) | Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA | Descriptor: | CBL E3 ubiquitin protein ligase | Authors: | Hamada, T, Hirota, H, Lin, Y.-J, Guntert, P, Kurosaki, C, Izumi, K, Yoshida, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-13 | Release date: | 2007-01-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA To be Published
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2N42
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![BU of 2n42 by Molmil](/molmil-images/mine/2n42) | EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data | Descriptor: | GTPase HRas | Authors: | Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-06-16 | Release date: | 2015-07-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
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8T8A
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![BU of 8t8a by Molmil](/molmil-images/mine/8t8a) | |
6Y1L
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![BU of 6y1l by Molmil](/molmil-images/mine/6y1l) | Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - L47R mutant | Descriptor: | DIETHYL PHOSPHONATE, FAB A.17 L47R mutant HEAVY CHAIN, FAB A.17 L47R mutant Light CHAIN, ... | Authors: | Chatziefthimiou, S, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | Deposit date: | 2020-02-12 | Release date: | 2020-09-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Y49
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![BU of 6y49 by Molmil](/molmil-images/mine/6y49) | Crystal structure of the paraoxon-modified A.17kappa antibody FAB fragment | Descriptor: | A.17kappa antibody FAB fragment - Heavy Chain, A.17kappa antibody FAB fragment - Light Chain, DIETHYL PHOSPHONATE | Authors: | Chatziefthimiou, S, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | Deposit date: | 2020-02-19 | Release date: | 2020-09-16 | Last modified: | 2020-09-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Y1K
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![BU of 6y1k by Molmil](/molmil-images/mine/6y1k) | Crystal structure of the unmodified A.17 antibody FAB fragment - L47R mutant | Descriptor: | FAB A.17 L47R mutant Heavy Chain, FAB A.17 L47R mutant Light Chain | Authors: | Chatziefthimiou, S, Stepanova, A, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | Deposit date: | 2020-02-12 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc.Natl.Acad.Sci.USA, 117, 2020
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2N46
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![BU of 2n46 by Molmil](/molmil-images/mine/2n46) | EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data | Descriptor: | GTPase HRas | Authors: | Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-06-17 | Release date: | 2015-07-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
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6Y1M
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![BU of 6y1m by Molmil](/molmil-images/mine/6y1m) | Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - L47K mutant | Descriptor: | DIETHYL PHOSPHONATE, FAB A.17 L47K mutant HEAVY CHAIN, FAB A.17 L47K mutant Light CHAIN | Authors: | Chatziefthimiou, S, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | Deposit date: | 2020-02-12 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc.Natl.Acad.Sci.USA, 117, 2020
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7SQI
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![BU of 7sqi by Molmil](/molmil-images/mine/7sqi) | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C14-crypto Acyl Carrier Protein, AcpP | Descriptor: | Acyl carrier protein, Beta-ketoacyl-ACP synthase I, N-{2-[(2Z)-3-chlorotetradec-2-enamido]ethyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | Authors: | Chen, A, Mindrebo, J.T, Davis, T.D, Noel, J.P, Burkart, M.D. | Deposit date: | 2021-11-05 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallogr D Struct Biol, 78, 2022
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1GD9
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![BU of 1gd9 by Molmil](/molmil-images/mine/1gd9) | CRYSTALL STRUCTURE OF PYROCOCCUS PROTEIN-A1 | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Harata, K, Matsui, I, Kuramitsu, S. | Deposit date: | 2000-09-22 | Release date: | 2001-09-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Temperature dependence of the enzyme-substrate recognition mechanism. J.Biochem., 129, 2001
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7SZ9
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![BU of 7sz9 by Molmil](/molmil-images/mine/7sz9) | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16:1-crypto Acyl Carrier Protein, AcpP | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(2-{[(9Z)-hexadec-9-enoyl]amino}ethyl)-beta-alaninamide, ... | Authors: | Mindrebo, J.T, Chen, A, Noel, J.P, Burkart, M.D. | Deposit date: | 2021-11-26 | Release date: | 2022-11-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallogr D Struct Biol, 78, 2022
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1GDE
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![BU of 1gde by Molmil](/molmil-images/mine/1gde) | CRYSTAL STRUCTURE OF PYROCOCCUS PROTEIN A-1 E-FORM | Descriptor: | ASPARTATE AMINOTRANSFERASE, GLUTAMIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Harata, K, Matsui, I, Kuramitsu, S. | Deposit date: | 2000-09-23 | Release date: | 2001-09-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Temperature dependence of the enzyme-substrate recognition mechanism. J.Biochem., 129, 2001
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1MPG
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![BU of 1mpg by Molmil](/molmil-images/mine/1mpg) | 3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI | Descriptor: | 3-METHYLADENINE DNA GLYCOSYLASE II, GLYCEROL | Authors: | Labahn, J, Schaerer, O.D, Long, A, Ezaz-Nikpay, K, Verdine, G.L, Ellenberger, T.E. | Deposit date: | 1997-10-28 | Release date: | 1998-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the excision repair of alkylation-damaged DNA. Cell(Cambridge,Mass.), 86, 1996
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1GIB
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![BU of 1gib by Molmil](/molmil-images/mine/1gib) | MU-CONOTOXIN GIIIB, NMR | Descriptor: | MU-CONOTOXIN GIIIB | Authors: | Hill, J.M, Alewood, P.F, Craik, D.J. | Deposit date: | 1996-04-17 | Release date: | 1996-11-08 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry, 35, 1996
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