1IZ5
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![BU of 1iz5 by Molmil](/molmil-images/mine/1iz5) | Pyrococcus furiosus PCNA mutant (Met73Leu, Asp143Ala, Asp147Ala): orthorhombic form | Descriptor: | Proliferating cell nuclear antigen | Authors: | Matsumiya, S, Ishino, S, Ishino, Y, Morikawa, K. | Deposit date: | 2002-09-23 | Release date: | 2003-04-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Intermolecular ion pairs maintain the toroidal structure of Pyrococcus furiosus PCNA PROTEIN SCI., 12, 2003
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1GE8
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1IY0
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![BU of 1iy0 by Molmil](/molmil-images/mine/1iy0) | Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus | Descriptor: | ATP-dependent metalloprotease FtsH, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Niwa, H, Tsuchiya, D, Makyio, H, Yoshida, M, Morikawa, K. | Deposit date: | 2002-07-10 | Release date: | 2002-11-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8 Structure, 10, 2002
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1ISQ
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![BU of 1isq by Molmil](/molmil-images/mine/1isq) | Pyrococcus furiosus PCNA complexed with RFCL PIP-box peptide | Descriptor: | Proliferating Cell Nuclear Antigen, replication factor C large subunit | Authors: | Matsumiya, S, Ishino, S, Ishino, Y, Morikawa, K. | Deposit date: | 2001-12-19 | Release date: | 2002-10-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Physical interaction between proliferating cell nuclear antigen and
replication factor C from Pyrococcus furiosus Genes Cells, 7, 2002
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1IY1
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![BU of 1iy1 by Molmil](/molmil-images/mine/1iy1) | Crystal structure of the FtsH ATPase domain with ADP from Thermus thermophilus | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent metalloprotease FtsH | Authors: | Niwa, H, Tsuchiya, D, Makyio, H, Yoshida, M, Morikawa, K. | Deposit date: | 2002-07-10 | Release date: | 2002-11-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8 Structure, 10, 2002
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2EGN
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![BU of 2egn by Molmil](/molmil-images/mine/2egn) | Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide | Descriptor: | General receptor for phosphoinositides 1-associated scaffold protein, mGluR5 C-terminal peptide | Authors: | Sugi, T, Oyama, T, Muto, T, Nakanishi, S, Morikawa, K, Jingami, H. | Deposit date: | 2007-03-01 | Release date: | 2007-05-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation Embo J., 26, 2007
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2E4X
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![BU of 2e4x by Molmil](/molmil-images/mine/2e4x) | Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 1S,3R-ACPD | Descriptor: | (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3 | Authors: | Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H. | Deposit date: | 2006-12-17 | Release date: | 2007-02-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structures of the extracellular regions of the group II/III metabotropic glutamate receptors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E4U
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![BU of 2e4u by Molmil](/molmil-images/mine/2e4u) | Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 3 | Authors: | Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H. | Deposit date: | 2006-12-17 | Release date: | 2007-02-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structures of the extracellular regions of the group II/III metabotropic glutamate receptors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2E4Y
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![BU of 2e4y by Molmil](/molmil-images/mine/2e4y) | Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 2R,4R-APDC | Descriptor: | (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3 | Authors: | Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H. | Deposit date: | 2006-12-17 | Release date: | 2007-02-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structures of the extracellular regions of the group II/III metabotropic glutamate receptors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2I56
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![BU of 2i56 by Molmil](/molmil-images/mine/2i56) | Crystal structure of L-Rhamnose Isomerase from Pseudomonas stutzeri with L-Rhamnose | Descriptor: | L-RHAMNOSE, L-rhamnose isomerase, ZINC ION | Authors: | Yoshida, H, Yamada, M, Takada, G, Izumori, K, Kamitori, S. | Deposit date: | 2006-08-24 | Release date: | 2006-12-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The Structures of l-Rhamnose Isomerase from Pseudomonas stutzeri in Complexes with l-Rhamnose and d-Allose Provide Insights into Broad Substrate Specificity J.Mol.Biol., 365, 2007
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2I57
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![BU of 2i57 by Molmil](/molmil-images/mine/2i57) | Crystal Structure of L-Rhamnose Isomerase from Pseudomonas stutzeri in Complex with D-Allose | Descriptor: | D-ALLOSE, L-rhamnose isomerase, ZINC ION | Authors: | Yoshida, H, Yamada, M, Takada, G, Izumori, K, Kamitori, S. | Deposit date: | 2006-08-24 | Release date: | 2006-12-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The Structures of l-Rhamnose Isomerase from Pseudomonas stutzeri in Complexes with l-Rhamnose and d-Allose Provide Insights into Broad Substrate Specificity J.Mol.Biol., 365, 2007
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2YY2
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![BU of 2yy2 by Molmil](/molmil-images/mine/2yy2) | Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Handa, N, Shirouzu, M, Terada, T, Omori, K, Kotera, J, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-27 | Release date: | 2007-10-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the human Phosphodiesterase 9A catalytic domain To be Published
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2ZVT
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![BU of 2zvt by Molmil](/molmil-images/mine/2zvt) | Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2 | Descriptor: | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Waku, T, Oyama, T, Shiraki, T, Morikawa, K. | Deposit date: | 2008-11-19 | Release date: | 2009-10-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands Febs Lett., 583, 2009
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3VSO
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![BU of 3vso by Molmil](/molmil-images/mine/3vso) | Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21 | Descriptor: | (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Oyama, T, Waku, T, Ohashi, M, Morikawa, K, Miyachi, H. | Deposit date: | 2012-04-30 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility Bioorg.Med.Chem., 21, 2013
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3VH5
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![BU of 3vh5 by Molmil](/molmil-images/mine/3vh5) | Crystal structure of the chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex, crystal form I | Descriptor: | CENP-S, CENP-T, CENP-W, ... | Authors: | Nishino, T, Takeuchi, K, Gascoigne, K.E, Suzuki, A, Hori, T, Oyama, T, Morikawa, K, Cheeseman, I.M, Fukagawa, T. | Deposit date: | 2011-08-23 | Release date: | 2012-03-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold Cell(Cambridge,Mass.), 148, 2012
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3VH6
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![BU of 3vh6 by Molmil](/molmil-images/mine/3vh6) | Crystal structure of the chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex, crystal form II | Descriptor: | CENP-S, CENP-T, CENP-W, ... | Authors: | Nishino, T, Takeuchi, K, Gascoigne, K.E, Suzuki, A, Hori, T, Oyama, T, Morikawa, K, Cheeseman, I.M, Fukagawa, T. | Deposit date: | 2011-08-23 | Release date: | 2012-03-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.351 Å) | Cite: | CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold Cell(Cambridge,Mass.), 148, 2012
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3WJ8
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![BU of 3wj8 by Molmil](/molmil-images/mine/3wj8) | Crystal Structure of DL-2-haloacid dehalogenase mutant with 2-bromo-2-methylpropionate | Descriptor: | 2-bromo-2-methylpropanoic acid, DL-2-haloacid dehalogenase, GLYCEROL | Authors: | Siwek, A, Omi, R, Hirotsu, K, Jitsumori, K, Esaki, N, Kurihara, T, Paneth, P. | Deposit date: | 2013-10-07 | Release date: | 2013-11-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Binding modes of DL-2-haloacid dehalogenase revealed by crystallography, modeling and isotope effects studies. Arch.Biochem.Biophys., 540, 2013
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3W0K
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3VSP
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![BU of 3vsp by Molmil](/molmil-images/mine/3vsp) | Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28 | Descriptor: | (2R)-2-benzyl-3-[3-({[4-(piperidin-1-yl)benzoyl]amino}methyl)-4-propoxyphenyl]propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Oyama, T, Waku, T, Ohashi, M, Morikawa, K, Miyachi, H. | Deposit date: | 2012-04-30 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28 To be Published
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5U7Q
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5U7R
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![BU of 5u7r by Molmil](/molmil-images/mine/5u7r) | Identification of A New Class of Potent Cdc7 Inhibitors Designed by Putative Pharmacophore Model: Synthesis and Biological Evaluation of 2,3-Dihydrothieno[3,2-d]pyrimidin-4(1H)-ones | Descriptor: | (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one, Rho-associated protein kinase 2 | Authors: | Hoffman, I.D, Skene, R.J. | Deposit date: | 2016-12-12 | Release date: | 2017-03-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones. Bioorg. Med. Chem., 25, 2017
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8X6R
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![BU of 8x6r by Molmil](/molmil-images/mine/8x6r) | KRasG12C in complex with inhibitor | Descriptor: | 1-[7-[6-ethenyl-8-ethoxy-7-(5-methyl-1~{H}-indazol-4-yl)-2-(1-methylpiperidin-4-yl)oxy-quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | Authors: | Amano, Y, Tateishi, Y. | Deposit date: | 2023-11-21 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. Bioorg.Med.Chem., 98, 2023
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3ABQ
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3ABR
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3ABO
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