Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2

Summary for 2ZVT

DescriptorPeroxisome proliferator-activated receptor gamma, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid (3 entities in total)
Functional Keywordsanti parallel helix sandwich, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65662.04
Waku, T.,Oyama, T.,Shiraki, T.,Morikawa, K. (deposition date: 2008-11-19, release date: 2009-10-06, Last modification date: 2011-07-13)
Primary citation
Waku, T.,Shiraki, T.,Oyama, T.,Morikawa, K.
Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands
Febs Lett., 583:320-324, 2009
PubMed: 19101554 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2008.12.017
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26725 3.8% 5.2% 12.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21