2ZVT
Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 286 | 32514.6 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (A, B) | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid | non-polymer | 316.4 | 2 | Chemie (PTG) PubChem (1444) PubChem (23654841) PubChem (177399882) PubChem (35026233) PubChem (44216415) PubChem (404025) PubChem (5283035) PubChem (5311211) PubChem (5353291) PubChem (6375741) PubChem (11324555) PubChem (11507959) PubChem (12068862) PubChem (12068863) PubChem (125310192) PubChem (131864269) PubChem (134689038) PubChem (138692927) PubChem (168311231) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A, B: 195 - 476 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | - | expression tag |
| Ser 192 | - | expression tag |
| His 193 | - | expression tag |
| Met 194 | - | expression tag |
| Ser 285 | Cys 313 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65029.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 632.9 | |
| All* | Total formula weight | 65662.0 |
