Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2

Summary for 2ZK1

Related2ZK0 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6
DescriptorPeroxisome proliferator-activated receptor gamma, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid (3 entities in total)
Functional Keywordsanti parallel helix sandwich, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65694.17
Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Morikawa, K. (deposition date: 2008-03-12, release date: 2009-02-24, Last modification date: 2011-07-13)
Primary citation
Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Maebara, K.,Kamiya, N.,Jingami, H.,Morikawa, K.
Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids
J.Mol.Biol., 385:188-199, 2009
PubMed: 18977231 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.10.039
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.301447.0%7.7%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report