6U62
| Raptor-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Rogala, K.B, Sabatini, D.M. | Deposit date: | 2019-08-29 | Release date: | 2019-10-30 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
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6ULG
| Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | Descriptor: | Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M. | Deposit date: | 2019-10-08 | Release date: | 2019-11-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell, 179, 2019
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6CES
| Cryo-EM structure of GATOR1-RAG | Descriptor: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | Authors: | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | Deposit date: | 2018-02-12 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
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6CET
| Cryo-EM structure of GATOR1 | Descriptor: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3 | Authors: | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | Deposit date: | 2018-02-12 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
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5VOK
| Crystal structure of the C7orf59-HBXIP dimer | Descriptor: | Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 | Authors: | Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C. | Deposit date: | 2017-05-03 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio, 2019
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7UHY
| Human GATOR2 complex | Descriptor: | GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... | Authors: | Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. | Deposit date: | 2022-03-27 | Release date: | 2022-07-20 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structure of the nutrient-sensing hub GATOR2. Nature, 607, 2022
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5I2C
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5T0N
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5DJ4
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6S6D
| Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. | Deposit date: | 2019-07-02 | Release date: | 2019-10-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6S6A
| Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. | Deposit date: | 2019-07-02 | Release date: | 2019-10-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6SB2
| cryo-EM structure of mTORC1 bound to active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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6SB0
| cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | Authors: | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | Deposit date: | 2019-07-18 | Release date: | 2019-10-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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