2YXX
 
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2YYR
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1X0J
 | | Crystal structure analysis of the N-terminal bromodomain of human Brd2 | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2 | | Authors: | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-03-23 | | Release date: | 2006-06-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for acetylated histone H4 recognition by the human Brd2 bromodomain
To be Published
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1WG0
 | | Structural comparison of Nas6p protein structures in two different crystal forms | | Descriptor: | Probable 26S proteasome regulatory subunit p28 | | Authors: | Nakamura, Y, Umehara, T, Tanaka, A, Horikoshi, M, Yokoyama, S, Padmanabhan, B, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-05-27 | | Release date: | 2005-06-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structural comparison of Nas6p protein structures in two different crystal forms
To be Published
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2DZO
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2YXY
 | | Crystarl structure of Hypothetical conserved protein, GK0453 | | Descriptor: | Hypothetical conserved protein, GK0453 | | Authors: | Nakamu, Y, Bessho, Y, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-27 | | Release date: | 2007-10-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426
Acta Crystallogr.,Sect.F, 69, 2013
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6IGI
 | | Crystal structure of FT condition 2 | | Descriptor: | 1,2-ETHANEDIOL, Protein FLOWERING LOCUS T | | Authors: | Watanabe, S, Nakamura, Y, Kanehara, K, Inaba, K. | | Deposit date: | 2018-09-25 | | Release date: | 2019-12-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | High-Resolution Crystal Structure of Arabidopsis FLOWERING LOCUS T Illuminates Its Phospholipid-Binding Site in Flowering.
Iscience, 21, 2019
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6IGG
 | | Crystal structure of FT condition 1 | | Descriptor: | 1,2-ETHANEDIOL, Protein FLOWERING LOCUS T | | Authors: | Watanabe, S, Nakamura, Y, Kanehara, K, Inaba, K. | | Deposit date: | 2018-09-25 | | Release date: | 2019-12-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | High-Resolution Crystal Structure of Arabidopsis FLOWERING LOCUS T Illuminates Its Phospholipid-Binding Site in Flowering.
Iscience, 21, 2019
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6IGJ
 | | Crystal structure of FT condition 4 | | Descriptor: | MAGNESIUM ION, Protein FLOWERING LOCUS T | | Authors: | Watanabe, S, Nakamura, Y, Kanehara, K, Inaba, K. | | Deposit date: | 2018-09-25 | | Release date: | 2019-12-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | High-Resolution Crystal Structure of Arabidopsis FLOWERING LOCUS T Illuminates Its Phospholipid-Binding Site in Flowering.
Iscience, 21, 2019
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6IGH
 | | Crystal structure of FT condition3 | | Descriptor: | 1,2-ETHANEDIOL, Protein FLOWERING LOCUS T | | Authors: | Watanabe, S, Nakamura, Y, Kanehara, K, Inaba, K. | | Deposit date: | 2018-09-25 | | Release date: | 2019-12-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.01 Å) | | Cite: | High-Resolution Crystal Structure of Arabidopsis FLOWERING LOCUS T Illuminates Its Phospholipid-Binding Site in Flowering.
Iscience, 21, 2019
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2DVS
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | Descriptor: | bromodomain-containing protein 2, histone H4 | | Authors: | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-08-01 | | Release date: | 2007-08-07 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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2DVR
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | Descriptor: | bromodomain-containing protein 2, histone H4 | | Authors: | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-08-01 | | Release date: | 2007-08-07 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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2DVQ
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | Descriptor: | Bromodomain-containing protein 2, histone H4 | | Authors: | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-08-01 | | Release date: | 2007-08-07 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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1EH1
 | | RIBOSOME RECYCLING FACTOR FROM THERMUS THERMOPHILUS | | Descriptor: | RIBOSOME RECYCLING FACTOR | | Authors: | Toyoda, T, Tin, O.F, Ito, K, Fujiwara, T, Kumasaka, T, Yamamoto, M, Garber, M.B, Nakamura, Y. | | Deposit date: | 2000-02-18 | | Release date: | 2000-11-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure combined with genetic analysis of the Thermus thermophilus ribosome recycling factor shows that a flexible hinge may act as a functional switch.
RNA, 6, 2000
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2YYV
 | | Crystal structure of uncharacterized conserved protein from Thermotoga maritima | | Descriptor: | Probable 2-phosphosulfolactate phosphatase | | Authors: | Nakagawa, N, Nakamura, Y, Bessho, Y, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-02 | | Release date: | 2007-11-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of uncharacterized conserved protein from Thermotoga maritima
To be Published
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2YYU
 | | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus | | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase | | Authors: | Kanagawa, M, Baba, S, Nakamura, Y, Bessho, Y, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-02 | | Release date: | 2007-11-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus
To be Published
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2YYT
 | | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus | | Descriptor: | Orotidine 5'-phosphate decarboxylase | | Authors: | Kanagawa, M, Baba, S, Nakamura, Y, Bessho, Y, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-02 | | Release date: | 2007-11-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus
To be Published
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2YZO
 | | Crystal structure of uncharacterized conserved protein from Thermotoga maritima | | Descriptor: | D-MALATE, Probable 2-phosphosulfolactate phosphatase | | Authors: | Nakagawa, N, Nakamura, Y, Bessho, Y, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-06 | | Release date: | 2007-11-06 | | Last modified: | 2012-02-15 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of uncharacterized conserved protein from Thermotoga maritima
To be Published
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2RRC
 | | Solution Structure of RNA aptamer against AML1 Runt domain | | Descriptor: | 5'-R(P*GP*GP*AP*CP*CP*CP*(AP7)P*CP*CP*AP*CP*GP*GP*CP*GP*AP*GP*GP*UP*CP*CP*A)-3' | | Authors: | Nomura, Y, Fujiwara, K, Chiba, M, Fukunaga, J, Tanaka, Y, Iibuchi, H, Tanaka, T, Nakamura, Y, Kawai, G, Kozu, T, Sakamoto, T. | | Deposit date: | 2010-06-23 | | Release date: | 2011-06-29 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A novel high affinity RNA motif that mimics DNA in AML1 Runt domain binding
To be Published
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2N37
 | | Solution structure of AVR-Pia | | Descriptor: | AVR-Pia protein | | Authors: | Ose, T, Oikawa, A, Nakamura, Y, Maenaka, K, Higuchi, Y, Satoh, Y, Fujiwara, S, Demura, M, Sone, T. | | Deposit date: | 2015-05-25 | | Release date: | 2015-10-14 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an avirulence protein, AVR-Pia, from Magnaporthe oryzae
J.Biomol.Nmr, 63, 2015
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2YRN
 | | Solution structure of the CH domain from Human Neuron navigator 2 | | Descriptor: | Neuron navigator 2 isoform 4 | | Authors: | Tomizawa, T, Tochio, N, Koshiba, S, Inoue, M, Nakamura, Y, Furukawa, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-02 | | Release date: | 2008-02-12 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the CH domain from Human Neuron navigator 2
To be Published
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3W1F
 | | Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide | | Descriptor: | 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide, Dual specificity protein kinase TTK | | Authors: | Kusakabe, K, Ide, N, Daigo, Y, Tachibana, Y, Itoh, T, Yamamoto, T, Hashizume, H, Hato, Y, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Yasuo, K, Maeda, M, Higaki, M, Ueda, K, Yoshizawa, H, Baba, Y, Shiota, T, Murai, H, Nakamura, Y. | | Deposit date: | 2012-11-14 | | Release date: | 2013-06-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)
J.Med.Chem., 56, 2013
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3VQU
 | | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide | | Descriptor: | 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide, Dual specificity protein kinase TTK, IODIDE ION | | Authors: | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Higashino, K, Okano, Y, Tadano, G, Tachibana, Y, Sato, Y, Inoue, M, Wada, T, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Tagashira, S, Kido, Y, Sakamoto, S, Yasuo, K, Maeda, M, Yamamoto, T, Higaki, M, Endoh, T, Ueda, K, Shiota, T, Murai, H, Nakamura, Y. | | Deposit date: | 2012-03-30 | | Release date: | 2012-06-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
Acs Med.Chem.Lett., 3, 2012
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3WZK
 | | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH N-cyclopropyl-4-(8-((thiophen-2-ylmethyl)amino)imidazo[1,2-a]pyrazin-3-yl)benzamide | | Descriptor: | CHLORIDE ION, Dual specificity protein kinase TTK, N-cyclopropyl-4-{8-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide | | Authors: | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Yamamoto, T, Kojima, E, Mitsuoka, Y, Tadano, G, Tagashira, S, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Ando, S, Maeda, M, Higaki, M, Yoshizawa, H, Mura, H, Nakamura, Y. | | Deposit date: | 2014-09-29 | | Release date: | 2015-02-11 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
J.Med.Chem., 58, 2015
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3WYY
 | | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)-3-(4-((6-(((3s,5s,7s)-adamantan-1-yl)amino)-4-amino-5-cyanopyridin-2-yl)amino)-2-(cyanomethoxy)phenyl)-N-(2-methoxyethyl)acrylamide | | Descriptor: | (2E)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-N-(2-methoxyethyl)prop-2-enamide, Dual specificity protein kinase TTK | | Authors: | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Yamamoto, T, Kojima, E, Mitsuoka, Y, Tadano, G, Tagashira, S, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Ando, S, Maeda, M, Higaki, M, Yoshizawa, H, Murai, H, Nakamura, Y. | | Deposit date: | 2014-09-10 | | Release date: | 2015-04-08 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
Bioorg.Med.Chem., 23, 2015
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