3VQU
CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide
Summary for 3VQU
Entry DOI | 10.2210/pdb3vqu/pdb |
Descriptor | Dual specificity protein kinase TTK, IODIDE ION, 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide, ... (4 entities in total) |
Functional Keywords | kinase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38039.71 |
Authors | Kusakabe, K.,Ide, N.,Daigo, Y.,Itoh, T.,Higashino, K.,Okano, Y.,Tadano, G.,Tachibana, Y.,Sato, Y.,Inoue, M.,Wada, T.,Iguchi, M.,Kanazawa, T.,Ishioka, Y.,Dohi, K.,Tagashira, S.,Kido, Y.,Sakamoto, S.,Yasuo, K.,Maeda, M.,Yamamoto, T.,Higaki, M.,Endoh, T.,Ueda, K.,Shiota, T.,Murai, H.,Nakamura, Y. (deposition date: 2012-03-30, release date: 2012-06-27, Last modification date: 2024-03-20) |
Primary citation | Kusakabe, K.,Ide, N.,Daigo, Y.,Itoh, T.,Higashino, K.,Okano, Y.,Tadano, G.,Tachibana, Y.,Sato, Y.,Inoue, M.,Wada, T.,Iguchi, M.,Kanazawa, T.,Ishioka, Y.,Dohi, K.,Tagashira, S.,Kido, Y.,Sakamoto, S.,Yasuo, K.,Maeda, M.,Yamamoto, T.,Higaki, M.,Endoh, T.,Ueda, K.,Shiota, T.,Murai, H.,Nakamura, Y. Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. Acs Med.Chem.Lett., 3:560-564, 2012 Cited by PubMed: 24900510DOI: 10.1021/ml3000879 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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