8T2H
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![BU of 8t2h by Molmil](/molmil-images/mine/8t2h) | DYRK1A complex with DYR530 | Descriptor: | (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL, ... | Authors: | Montfort, W.R, Basantes, L.E. | Deposit date: | 2023-06-06 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue To Be Published
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2TSC
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![BU of 2tsc by Molmil](/molmil-images/mine/2tsc) | STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Montfort, W.R, Stroud, R.M. | Deposit date: | 1991-07-03 | Release date: | 1991-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry, 29, 1990
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3PAV
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2FTQ
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![BU of 2ftq by Molmil](/molmil-images/mine/2ftq) | E. coli thymidylate synthase at 1.8 A resolution | Descriptor: | PHOSPHATE ION, SULFATE ION, Thymidylate synthase | Authors: | Montfort, W.R, Roberts, S.A. | Deposit date: | 2006-01-24 | Release date: | 2006-05-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Subtle Conformational Differences between Escherichia coli Thymidylate Synthase and Specific Mutants of this Enzyme To be Published
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3FLL
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![BU of 3fll by Molmil](/molmil-images/mine/3fll) | Crystal structure of E55Q mutant of nitrophorin 4 | Descriptor: | AMMONIA, Nitrophorin-4, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Montfort, W.R, Weichsel, A. | Deposit date: | 2008-12-18 | Release date: | 2009-02-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes. J.Am.Chem.Soc., 131, 2009
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3QQX
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![BU of 3qqx by Molmil](/molmil-images/mine/3qqx) | Reduced Native Intermediate of the Multicopper Oxidase CueO | Descriptor: | Blue copper oxidase CueO, COPPER (I) ION, COPPER (II) ION, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2011-02-16 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | CueO E506D Mutant: Crystal Structure of Reduced Native Intermediate, Kinetics, and Impairment of Product Release To be Published
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3NSD
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![BU of 3nsd by Molmil](/molmil-images/mine/3nsd) | Silver bound to the multicopper oxidase CueO (untagged) | Descriptor: | Blue copper oxidase cueO, COPPER (II) ION, OXYGEN ATOM, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2010-07-01 | Release date: | 2011-08-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
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3OD3
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![BU of 3od3 by Molmil](/molmil-images/mine/3od3) | CueO at 1.1 A resolution including residues in previously disordered region | Descriptor: | 1,2-ETHANEDIOL, Blue copper oxidase cueO, COPPER (II) ION, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2010-08-10 | Release date: | 2011-09-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
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2FTN
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![BU of 2ftn by Molmil](/molmil-images/mine/2ftn) | E. coli thymidylate synthase Y94F mutant | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Montfort, W.R, Roberts, S.A. | Deposit date: | 2006-01-24 | Release date: | 2006-05-02 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of the Y94F mutant of Escherichia coli thymidylate synthase. ACTA CRYSTALLOGR.,SECT.F, 62, 2006
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4OO5
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4OO4
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1ML7
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![BU of 1ml7 by Molmil](/molmil-images/mine/1ml7) | Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole | Descriptor: | 4-IODOPYRAZOLE, 5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC ACID FERROUS COMPLEX, nitrophorin 4 | Authors: | Berry, R.E, Ding, X.D, Weichsel, A, Montfort, W.R, Walker, F.A. | Deposit date: | 2002-08-30 | Release date: | 2002-09-20 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4 J.Biol.Inorg.Chem., 9, 2004
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3C78
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3UKO
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6MX5
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6WQE
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![BU of 6wqe by Molmil](/molmil-images/mine/6wqe) | Solution Structure of the IWP-051-bound H-NOX from Shewanella woodyi in the Fe(II)CO ligation state | Descriptor: | 5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-ol, CARBON MONOXIDE, Heme NO binding domain protein, ... | Authors: | Chen, C.Y, Lee, W, Montfort, W.R. | Deposit date: | 2020-04-28 | Release date: | 2020-07-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051. Protein Sci., 30, 2021
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4NP1
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![BU of 4np1 by Molmil](/molmil-images/mine/4np1) | NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE | Descriptor: | NITRIC OXIDE, NITROPHORIN 1, PHOSPHATE ION, ... | Authors: | Weichsel, A, Andersen, J.F, Walker, F.A, Montfort, W.R. | Deposit date: | 1998-06-26 | Release date: | 1998-11-11 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Nitric Oxide Binding to the Ferri-and Ferroheme States of Nitrophorin 1, a Reversible No-Binding Heme Protein from the Saliva of the Blood-Sucking Insect, Rhodnius Prolixus To be Published
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4GRJ
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6OCV
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6DXI
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3M9K
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![BU of 3m9k by Molmil](/molmil-images/mine/3m9k) | Crystal structure of human thioredoxin C69/73S double-mutant, oxidized form | Descriptor: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, SULFATE ION, Thioredoxin | Authors: | Weichsel, A, Montfort, W.R. | Deposit date: | 2010-03-22 | Release date: | 2010-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site. Protein Sci., 19, 2010
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3M9J
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3FGC
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![BU of 3fgc by Molmil](/molmil-images/mine/3fgc) | Crystal Structure of the Bacterial Luciferase:Flavin Complex Reveals the Basis of Intersubunit Communication | Descriptor: | Alkanal monooxygenase alpha chain, Alkanal monooxygenase beta chain, FLAVIN MONONUCLEOTIDE, ... | Authors: | Campbell, Z.T, Weichsel, A, Montfort, W.R, Baldwin, T.O. | Deposit date: | 2008-12-05 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the bacterial luciferase/flavin complex provides insight into the function of the beta subunit. Biochemistry, 48, 2009
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4GNW
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2NP1
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