1ZJK
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![BU of 1zjk by Molmil](/molmil-images/mine/1zjk) | Crystal structure of the zymogen catalytic region of human MASP-2 | Descriptor: | Mannan-binding lectin serine protease 2 | Authors: | Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P. | Deposit date: | 2005-04-29 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations J.Biol.Chem., 280, 2005
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2QY0
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![BU of 2qy0 by Molmil](/molmil-images/mine/2qy0) | Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts | Descriptor: | Complement C1r subcomponent, GLYCEROL | Authors: | Kardos, J, Harmat, V, Pallo, A, Barabas, O, Szilagyi, K, Graf, L, Naray-Szabo, G, Goto, Y, Zavodszky, P, Gal, P. | Deposit date: | 2007-08-13 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol.Immunol., 45, 2008
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3TVJ
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![BU of 3tvj by Molmil](/molmil-images/mine/3tvj) | Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold | Descriptor: | Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, Protease inhibitor SGPI-2, ... | Authors: | Heja, D, Harmat, V, Dobo, J, Szasz, R, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G. | Deposit date: | 2011-09-20 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287, 2012
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1Q3X
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![BU of 1q3x by Molmil](/molmil-images/mine/1q3x) | Crystal structure of the catalytic region of human MASP-2 | Descriptor: | GLYCEROL, Mannan-binding lectin serine protease 2, SODIUM ION | Authors: | Harmat, V, Gal, P, Kardos, J, Szilagyi, K, Ambrus, G, Naray-Szabo, G, Zavodszky, P. | Deposit date: | 2003-08-01 | Release date: | 2004-08-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions J.Mol.Biol., 342, 2004
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3GOV
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![BU of 3gov by Molmil](/molmil-images/mine/3gov) | Crystal structure of the catalytic region of human MASP-1 | Descriptor: | GLYCEROL, MASP-1 | Authors: | Harmat, V, Dobo, J, Beinrohr, L, Sebestyen, E, Zavodszky, P, Gal, P. | Deposit date: | 2009-03-20 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J.Immunol., 183, 2009
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2OAY
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![BU of 2oay by Molmil](/molmil-images/mine/2oay) | Crystal structure of latent human C1-inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Plasma protease C1 inhibitor | Authors: | Harmat, V, Beinrohr, L, Gal, P, Dobo, J. | Deposit date: | 2006-12-18 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease J.Biol.Chem., 282, 2007
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4DJZ
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![BU of 4djz by Molmil](/molmil-images/mine/4djz) | Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold | Descriptor: | Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2 | Authors: | Heja, D, Harmat, V, Fodor, K, Wilmanns, M, Dobo, J, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G. | Deposit date: | 2012-02-03 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287, 2012
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7ARX
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![BU of 7arx by Molmil](/molmil-images/mine/7arx) | Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1 | Descriptor: | DI(HYDROXYETHYL)ETHER, Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor | Authors: | Durvanger, Z, Harmat, V, Dobo, J, Megyeri, M. | Deposit date: | 2020-10-26 | Release date: | 2021-11-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides. Acs Chem.Biol., 17, 2022
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7PQN
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![BU of 7pqn by Molmil](/molmil-images/mine/7pqn) | Catalytic fragment of MASP-2 in complex with ecotin | Descriptor: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 2 A chain, ... | Authors: | Harmat, V, Fodor, K, Heja, D. | Deposit date: | 2021-09-17 | Release date: | 2022-05-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.400015 Å) | Cite: | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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7PQO
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![BU of 7pqo by Molmil](/molmil-images/mine/7pqo) | Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin | Descriptor: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 1, ... | Authors: | Harmat, V, Fodor, K, Heja, D. | Deposit date: | 2021-09-17 | Release date: | 2022-05-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.39 Å) | Cite: | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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4IGD
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![BU of 4igd by Molmil](/molmil-images/mine/4igd) | Crystal structure of the zymogen catalytic region of Human MASP-1 | Descriptor: | GLYCEROL, Mannan-binding lectin serine protease 1 | Authors: | Harmat, V, Megyeri, M, Vegh, A, Dobo, J. | Deposit date: | 2012-12-17 | Release date: | 2013-02-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway J.Biol.Chem., 288, 2013
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4LMF
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![BU of 4lmf by Molmil](/molmil-images/mine/4lmf) | C1s CUB1-EGF-CUB2 | Descriptor: | CALCIUM ION, Complement C1s subcomponent heavy chain, SODIUM ION | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. | Deposit date: | 2013-07-10 | Release date: | 2013-08-07 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.921 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LOS
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![BU of 4los by Molmil](/molmil-images/mine/4los) | C1s CUB2-CCP1 | Descriptor: | CALCIUM ION, Complement C1s subcomponent heavy chain | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E, Gingras, A.R. | Deposit date: | 2013-07-13 | Release date: | 2013-08-07 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LOT
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![BU of 4lot by Molmil](/molmil-images/mine/4lot) | C1s CUB2-CCP1-CCP2 | Descriptor: | Complement C1s subcomponent heavy chain | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. | Deposit date: | 2013-07-13 | Release date: | 2013-08-07 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LOR
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![BU of 4lor by Molmil](/molmil-images/mine/4lor) | C1s CUB1-EGF-CUB2 in complex with a collagen-like peptide from C1q | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C1s subcomponent heavy chain, ... | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. | Deposit date: | 2013-07-13 | Release date: | 2013-08-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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5JPM
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![BU of 5jpm by Molmil](/molmil-images/mine/5jpm) | Structure of the complex of human complement C4 with MASP-2 rebuilt using iMDFF | Descriptor: | Complement C4-A, Mannan-binding lectin serine protease 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Croll, T.I, Andersen, G.R. | Deposit date: | 2016-05-03 | Release date: | 2016-08-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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5JPN
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![BU of 5jpn by Molmil](/molmil-images/mine/5jpn) | Structure of human complement C4 rebuilt using iMDFF | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ... | Authors: | Croll, T.I, Andersen, G.R. | Deposit date: | 2016-05-03 | Release date: | 2016-08-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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